Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis

被引：40

作者：

Bin, Bum-Ho ^{[1
]}

Bhin, Jinhyuk ^{[2
]}

Takaishi, Mikiro ^{[3
]}

Toyoshima, Koh-ei ^{[4
]}

Kawamata, Saeko ^{[5
]}

Ito, Kana ^{[5
]}

Hara, Takafumi ^{[5
]}

Watanabe, Takashi ^{[6
]}

Irie, Tarou ^{[7
]}

Takagishi, Teruhisa ^{[5
]}

Lee, Su-Hyon ^{[8
]}

Jung, Haeng-Sun ^{[8
]}

Rho, Sangchul ^{[9
]}

Seo, Juyeon ^{[10
]}

Choi, Dong-Hwa ^{[11
]}

Hwang, Daehee ^{[12
]}

Koseki, Haruhiko ^{[13
]}

Ohara, Osamu

Sano, Shigetoshi

Tsuji, Takashi ^{[4
]}

Mishima, Kenji ^{[1
]}

Fukada, Toshiyuki ^{[1
,5
,14
]}

机构：

[1] Showa Univ, Sch Dent, Dept Oral Diagnost Sci, Div Pathol, Tokyo 1428555, Japan

[2] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

[3] Kochi Univ, Kochi Med Sch, Dept Dermatol, Nankoku, Kochi 7838505, Japan

[4] RIKEN, Lab Organ Regenerat, Ctr Dev Biol, Kobe, Hyogo 6500047, Japan

[5] Tokushima Bunri Univ, Fac Pharmaceut Sci, Mol & Cellular Physiol, Tokushima 7708514, Japan

[6] RIKEN, Lab Integrat Genom, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

[7] Iwate Med Univ, Dept Pathol, Div Anat & Cellular Pathol, Morioka, Iwate 0283694, Japan

[8] Bio Solut Corp, Seoul 139743, South Korea

[9] Pohang Univ Sci & Technol, Inst Environm & Energy Technol, Pohang 37673, South Korea

[10] Beauty Food Res Team, Amorepacif R&D Unit, Beauty Longev Sci Res Div, Yongin 17074, South Korea

[11] Gyeonggi Inst Sci & Technol Promot, Gyeonggi Bio Ctr, Suwon 443270, South Korea

[12] Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea

[13] RIKEN, Ctr Integrat Med Sci, Lab Dev Genet, Yokohama, Kanagawa 2300042, Japan

[14] RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2017年 / 114卷 / 46期

基金：

新加坡国家研究基金会;

关键词：

zinc transporter; ZIP10; skin epidermis; hair follicle; development; ACRODERMATITIS-ENTEROPATHICA; STEM-CELLS; GENE-EXPRESSION; HAIR FOLLICLE; DNA-BINDING; RNA-SEQ; P63; DIFFERENTIATION; SKIN; PROLIFERATION;

D O I：

10.1073/pnas.1710726114

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating Zip10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation. Both ZIP10 and p63 are significantly increased during epidermal development, in which ZIP10-mediated zinc influx promotes p63 transactivation. Collectively, these results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.

引用

页码：12243 / 12248

页数：6

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