Comparative Study of Molecularly Imprinted Polymer and Magnetic Molecular Imprinted Nanoparticles as Recognition Sites for the Potentiometric Determination of Gemifloxacin Mesylate

被引:12
|
作者
Abdallahl, Nehad A. [1 ,2 ]
Ibhrahim, Heba F. [2 ]
Hegabe, Nayira H. [2 ]
机构
[1] Taibah Univ, Fac Pharm, Pharmacognosy & Pharmaceut Chem Dept, Al Madinah Al Mounawarah 41477, Saudi Arabia
[2] Ain Shams Univ, Fac Pharm, Expt & Adv Pharmaceut Res Unit, Cairo 1156, Egypt
来源
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2017年 / 12卷 / 11期
关键词
Gemifloxacin; molecularly imprinted; magnetic nanoparticles; carbon paste electrode; STABILITY-INDICATING ASSAY; ION-SELECTIVE ELECTRODES; PHARMACEUTICAL FORMULATIONS; CHROMATOGRAPHY; SENSORS; PLASMA; MS/MS; ACID; RAT;
D O I
10.20964/2017.11.74
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
Two nanoparticles based potentiometric sensors were fabricated for the selective determination of gemifloxacin mesylate. The first sensor was based on the formation of molecularly imprinted polymer nanoparticles using methacrylic acid as a functional monomer, trimethylolpropane trimethacrylate as a crosslinker and azobisisobutyronitrile as the initiator. The second sensor was based on the use of Fe3O4 magnetic nanoparticles as core shells for the molecularly imprinted polymer. The developed sensors showed high selectivity, stability and sensitivity with wide concentration ranges of 1 x 10(-3) - 1 x 10(-8) mol L-1 and 1 x 10(-3) - 1 x 10(-10) mol L-1 for sensors 1 and 2, respectively. They were efficiently applied for the determination of gemifloxacin mesylate in bulk, pharmaceutical tablets and spiked human plasma.
引用
收藏
页码:10894 / 10910
页数:17
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