A rare case of ovarian gonadoblastoma flourishing into malignant mixed germ cell tumour with review of literature

被引：1

作者：

Patel, Tarang ^{[1
]}

Jakhetiya, Bhamini ^{[2
]}

Jakhetiya, Ashish ^{[3
]}

Meena, Virendrakumar ^{[4
]}

机构：

[1] All India Inst Med Sci, Dept Pathol, Rajkot, Gujarat, India

[2] Geetanjali Med Coll & Hosp, Dept Gynecol & Obstet, Udaipur, Rajasthan, India

[3] Geetanjali Med Coll & Hosp, Dept Surg Oncol, Udaipur, Rajasthan, India

[4] Geetanjali Med Coll & Hosp, Dept Radiodiag, Udaipur, Rajasthan, India

来源：

INTERNATIONAL CANCER CONFERENCE JOURNAL | 2022年 / 11卷 / 02期

关键词：

Ovarian gonadoblastoma; Immature teratoma; Dysgerminoma; PLAP; SALL4; Inhibin; DYSGERMINOMA; KARYOTYPE; NEOPLASMS; WOMAN;

D O I：

10.1007/s13691-021-00531-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gonadoblastoma is an extremely rare neoplasm of the ovary showing admixture of germ cells and sex cord cells. It may be associated with gonadal dysgenesis. Gonadoblastoma cells may give rise to individual germ cell tumours or mixed germ cell tumours with variable tumour components. Very few cases of ovarian gonadoblastoma admixed with malignant germ cell tumours have been recorded worldwide. Because of the rareness of the tumour, a component of gonadoblastoma might be overlooked on microscopic examination. Here we report a rare case of ovarian gonadoblastoma giving rise to an admixture of immature teratoma and dysgerminoma. We discuss microscopic features, immunohistochemistry findings and review of literature.

引用

页码：114 / 118

页数：5

共 16 条

[1] Malignant Mixed Germ Cell Tumor Overgrowing a Gonadoblastoma in a Female With a 46, XX Karyotype: A Case Report [J].

Arafah, Maria A. ;

Raddaoui, Leen E. .

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2018, 26 (03) :287-292

[2] Mixed Gonadal Germ Cell Tumor Composed of a Spermatocytic Tumor-Like Component and Germinoma Arising in Gonadoblastoma in a Phenotypic Woman With a 46, XX Peripheral Karyotype Report of the First Case [J].

Gru, Alejandro A. ;

Williams, Eli S. ;

Cao, Dengfeng .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (09) :1290-1297

[3]

HART WR, 1979, CANCER-AM CANCER SOC, V43, P669, DOI 10.1002/1097-0142(197902)43:2<669::AID-CNCR2820430239>3.0.CO

[4]

2-H

[5] Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology [J].

Kulkarni, Maithili Mandar ;

Khandeparkar, Siddhi Gaurish Sinai ;

Joshi, Avinash R. ;

Bhayekar, Pallavi V. .

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2016, 59 (04) :527-529

[6]

Longacre, 2020, WHO CLASSIFICATION F, V70, P131

[7]

Longacre TA, 2020, WHO CLASSIFICATION F, V70, P140

[8] Gonadoblastoma-Associated Mixed Gonadal Germ Cell Tumor with Dysgerminoma and Hepatoid Yolk Sac Tumor Components in 46XY Gonadal Dysgenesis [J].

Losada, Daniele M. ;

Benetti-Pinto, Cristina L. ;

Andrade, Liliana A. L. A. .

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, 2019, 32 (05) :558-560

[9]

Palma I, 2013, DIS MARKERS, V34, P419, DOI [10.3233/DMA-130972, 10.1155/2013/951751]

[10] Germ Cell Tumors in Dysgenetic Gonads [J].

Piazza, Mauri Jose ;

Urbanetz, Almir Antonio .

CLINICS, 2019, 74

← 1 2 →