Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia

被引:11
作者
Lu, Yanxia [1 ]
Fulop, Tamas [2 ]
Gwee, Xinyi [3 ]
Lee, Tih Shih [4 ]
Lim, Wee Shiong [5 ]
Chong, Mei Sian [6 ]
Yap, Philip Lin Kiat [7 ]
Yap, Keng Bee [8 ]
Pan, Fang [1 ]
Ng, Tze-Pin [3 ]
机构
[1] Shandong Univ, Sch Basic Med Sci, Cheeloo Coll Med, Dept Med Psychol & Eth, Jinan, Peoples R China
[2] Univ Sherbrooke, Res Ctr Aging, Dept Med, Sherbrooke, PQ, Canada
[3] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Psychol Med,Gerontol Res Programme, Singapore, Singapore
[4] Duke NUS Sch Med, Singapore, Singapore
[5] Tan Tock Seng Hosp, Dept Geriatr Med, Singapore, Singapore
[6] Mt Elizabeth Hosp, Singapore, Singapore
[7] Khoo Teck Puat Hosp, Dept Geriatr Med, Singapore, Singapore
[8] Ng Teng Fong Hosp, Dept Geriatr Med, Singapore, Singapore
基金
英国医学研究理事会;
关键词
Cardiometabolic and vascular disease; Mild cognitive impairment; Dementia; MENTAL-STATE-EXAMINATION; OLDER CHINESE ADULTS; ALZHEIMER-DISEASE; TEST-PERFORMANCE; DECLINE; STROKE; RISK; ASSOCIATION; PATHOLOGY;
D O I
10.1159/000521547
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Introduction: There is empirical evidence that cardiovascular risk factors and vascular pathology contribute to cognitive impairment and dementia. Methods: We profiled cardiometabolic and vascular disease (CMVD) and CMVD burden in community-living older adults in the Singapore Longitudinal Ageing Study cohort and examined the association of CMVD risk markers with the prevalence and incidence of mild cognitive impairment (MCI) and dementia from a median 3.8 years of follow-up. Results: Prevalent MCI and dementia, compared with normal cognition, was associated with higher proportions of persons with any CMVD, hypertension, diabetes, coronary heart disease, atrial fibrillation, or stroke. Diabetes, stroke, and the number of CMVD risk markers remained significantly associated with dementia or MCI after adjusting for age, sex, formal education level, APOE-epsilon 4 genotype, and level of physical, social, or productive activities, with odds ratios ranging from 1.3 to 5.7. Among cognitively normal participants who were followed up, any CMVD risk factor, dyslipidemia, diabetes, or heart failure at baseline predicted incident MCI or its progression to dementia after adjusting for potential confounders. Conclusion: Older adults with higher burden of CMVD, driven especially by diabetes, are likely to increase the risk of prevalent and incident MCI and dementia.
引用
收藏
页码:1061 / 1069
页数:9
相关论文
共 44 条
[1]   Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls [J].
Barnes, Josephine ;
Carmichael, Owen T. ;
Leung, Kelvin K. ;
Schwarz, Christopher ;
Ridgway, Gerard R. ;
Bartlett, Jonathan W. ;
Malone, Ian B. ;
Schott, Jonathan M. ;
Rossor, Martin N. ;
Biessels, Geert Jan ;
DeCarli, Charlie ;
Fox, Nick C. .
NEUROBIOLOGY OF AGING, 2013, 34 (08) :1996-2002
[2]   The link between type 2 diabetes and dementia: from biomarkers to treatment [J].
Beeri, Michal Schnaider ;
Bendlin, Barbara B. .
LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (09) :736-738
[3]   Screening for dementia: a review of self- and informant-assessment instruments [J].
Cherbuin, Nicolas ;
Anstey, Kaarin J. ;
Lipnicki, Darren M. .
INTERNATIONAL PSYCHOGERIATRICS, 2008, 20 (03) :431-458
[4]   Unconditional and Conditional Standards Using Cognitive Function Curves for the Modified Mini-Mental State Exam: Cross-Sectional and Longitudinal Analyses in Older Chinese Adults in Singapore [J].
Cheung, Yin Bun ;
Xu, Ying ;
Feng, Lei ;
Feng, Liang ;
Nyunt, Ma Shwe Zin ;
Chong, Mei Sian ;
Lim, Wee Shiong ;
Lee, Tih Shih ;
Yap, Philip ;
Yap, Keng Bee ;
Ng, Tze Pin .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2015, 23 (09) :915-924
[5]   Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis [J].
Ciesielska, Natalia ;
Sokolowski, Remigiusz ;
Mazur, Ewelina ;
Podhorecka, Marta ;
Polak-Szabela, Anna ;
Kedziora-Kornatowska, Kornelia .
PSYCHIATRIA POLSKA, 2016, 50 (05) :1039-1052
[6]   Brain microbleeds and Alzheimer's disease: innocent observation or key player? [J].
Cordonnier, Charlotte ;
van der Flier, Wiesje M. .
BRAIN, 2011, 134 :335-344
[7]   Long-Term Risk of Dementia Among Survivors of Ischemic or Hemorrhagic Stroke [J].
Corraini, Priscila ;
Henderson, Victor W. ;
Ording, Anne G. ;
Pedersen, Lars ;
Horvath-Puho, Erzsebet ;
Sorensen, Henrik T. .
STROKE, 2017, 48 (01) :180-+
[8]   Alzheimer disease as a vascular disorder - Nosological evidence [J].
de la Torre, JC .
STROKE, 2002, 33 (04) :1152-1162
[9]   Prevention of Vascular Cognitive Impairment [J].
Dichgans, Martin ;
Zietemann, Vera .
STROKE, 2012, 43 (11) :3137-U687
[10]   Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial:: a double-blind, active and placebo-controlled study [J].
Dienert, Hans-Christoph ;
Saccot, Ralph L. ;
Yusuft, Salim ;
Cotton, Daniel ;
Ounpuu, Stephanie ;
Lawton, William A. ;
Palesch, Yuko ;
Martin, Renee H. ;
Albers, Gregory W. ;
Bath, Philip ;
Bornstein, Natan ;
Chan, Bernard P. L. ;
Chen, Sien-Tsong ;
Cunha, Luis ;
Dahlof, Bjorn ;
De Keyser, Jacques ;
Donnan, Geoffrey A. ;
Estol, Conrado ;
Gorelick, Philip ;
Gu, Vivian ;
Hermansson, Karin ;
Hilbrich, Lutz ;
Kaste, Markku ;
Lu, Chuanzhen ;
Machnig, Thomas ;
Pais, Prem ;
Roberts, Robin ;
Skvortsova, Veronika ;
Teal, Philip ;
Toni, Danilo ;
VanderMaelen, Cam ;
Voigt, Thor ;
Weber, Michael ;
Yoon, Byung-Woo .
LANCET NEUROLOGY, 2008, 7 (10) :875-884