Complementary and contrasting roles of NK cells and T cells in pediatric umbilical cord blood transplantation

被引：24

作者：

Merindol, Natacha ^{[1
,3
,5
]}

Charrier, Emily ^{[2
,3
,4
,6
]}

Duval, Michel ^{[2
,3
,4
,7
]}

Soudeyns, Hugo ^{[1
,3
,5
,7
]}

机构：

[1] Ctr Rech CHU St Justine, Unite Immunopathol Virale, Montreal, PQ H3T 1C5, Canada

[2] CHU St Justine, Lab Immunol Sang Cordon, Montreal, PQ, Canada

[3] CHU St Justine, GRETISC, Ctr Cancerol Charles Bruneau, Montreal, PQ, Canada

[4] CHU St Justine, Dept Hematooncol, Montreal, PQ, Canada

[5] Univ Montreal, Fac Med, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[6] Univ Montreal, Fac Med, Dept Biomed Sci, Montreal, PQ H3C 3J7, Canada

[7] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2011年 / 90卷 / 01期

关键词：

primary cell; MHC; cytokines; molecules; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; NATURAL-KILLER-CELLS; VARICELLA-ZOSTER-VIRUS; ACUTE LYMPHOBLASTIC-LEUKEMIA; EX-VIVO EXPANSION; TUMOR GENE WT1; MINOR HISTOCOMPATIBILITY ANTIGENS; KIR-LIGAND INCOMPATIBILITY; HEMATOPOIETIC STEM-CELLS;

D O I：

10.1189/jlb.0111007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

UCBT has been used for almost 25 years to treat a variety of malignant and nonmalignant childhood diseases. The biological properties of NK cells and T cells and their implication in engraftment, immune reconstitution, OIs, leukemic relapse, and GvHD have been explored in the context of UCBT. These studies have established that lymphocytes have a major impact on the outcome of UCBT and that NK cells and T cells play complementary and contrasting roles in immune reconstitution and the GvL effect. Therefore, novel strategies to improve the outcome of UCBT recipients, including immunotherapeutic regimens, should be based on key immunologic features of UCB T lymphocytes and NK cells. J. Leukoc. Biol. 90: 49-60; 2011.

引用

收藏

页码：49 / 60

页数：12

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