Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia

被引：46
作者：
Chu, TW
Hu, SW
Wei, B
Wang, Y
Liu, XQ
Wang, XY [1 ]
机构：
[1] Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期
基金：
中国国家自然科学基金;
关键词：
4-nitroimidazole; hypoxia imaging agent; biodistribution; tumor;
D O I：
10.1016/j.bmcl.2003.11.017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N41PA) was synthesized. The biodistribution of Tc-99m-N41PA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that Tc-99m-N41PA would be a marker for imaging tumor hypoxia. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：747 / 749
页数：3
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