Possible prediction of the efficiency of chemotherapy in patients with Lymphoproliferative diseases based on MDR1 gene G2677T and C3435T Polymorphisms

被引：25
作者：
Goreva, OB [1 ]
Grishanova, AY
Mukhin, OV
Domnikova, NP
Lyakhovich, VV
机构：
[1] Russian Acad Med Sci, Inst Mol Biol & Biophys, Siberian Div, Novosibirsk, Russia
[2] State Reg Clin Hosp, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
MDR1/P glycoprotein; genetic polymorphism; lymphoproliferative diseases; drug resistance;
D O I：
10.1023/A:1026331326648
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Study of polymorphism in MDR1 gene exons 21 and 26 revealed that (TT)-T-2677 and (TT)-T-3435 alleles are not a factor predisposing to lymphoproliferative diseases, but they determine the efficiency chemotherapy. Individuals with (TT)-T-2677 and (TT)-T-3435 haplotypes are at highest risk of drug resistance. Association between genotypes G(2677)T and (CT)-T-3435 was detected in normal subjects and in patients with lymphoproliferative diseases.
引用
收藏
页码：183 / 185
页数：3
相关论文
共 9 条
  • [1] Biochemical, cellular, and pharmacological aspects of the multidrug transporter
    Ambudkar, SV
    Dey, S
    Hrycyna, CA
    Ramachandra, M
    Pastan, I
    Gottesman, MM
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 : 361 - 398
  • [2] MDR1 pharmacogenetics:: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    Ameyaw, MM
    Regateiro, F
    Li, T
    Liu, XH
    Tariq, M
    Mobarek, A
    Thornton, N
    Folayan, GO
    Githang'a, J
    Indalo, A
    Ofori-Adjei, D
    Price-Evans, DA
    McLeod, HL
    [J]. PHARMACOGENETICS, 2001, 11 (03): : 217 - 221
  • [3] Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    Cascorbi, I
    Gerloff, T
    Johne, A
    Meisel, C
    Hoffmeyer, S
    Schwab, M
    Schaeffeler, E
    Eichelbaum, M
    Brinkmann, U
    Roots, I
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) : 169 - 174
  • [4] CHEN CJ, 1990, J BIOL CHEM, V265, P506
  • [5] P-glycoprotein and multidrug resistance
    Gottesman, MM
    Pastan, I
    Ambudkar, SV
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (05) : 610 - 617
  • [6] Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
    Ito, S
    Ieiri, I
    Tanabe, M
    Suzuki, A
    Higuchi, S
    Otsubo, K
    [J]. PHARMACOGENETICS, 2001, 11 (02): : 175 - 184
  • [7] ABC drug transporters:: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2
    Kerb, R
    Hoffmeyer, S
    Brinkmann, U
    [J]. PHARMACOGENOMICS, 2001, 2 (01) : 51 - 64
  • [8] Identification of functionally variant MDR1 alleles among European Americans and African Americans
    Kim, RB
    Leake, BF
    Choo, EF
    Dresser, GK
    Kubba, SV
    Schwarz, UI
    Taylor, A
    Xie, HG
    McKinsey, J
    Zhou, S
    Lan, LB
    Schuetz, JD
    Schuetz, EG
    Wilkinson, GR
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 70 (02) : 189 - 199
  • [9] Genetic polymorphism in MDR-1:: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
    Mickley, LA
    Lee, JS
    Weng, Z
    Zhan, ZR
    Alvarez, M
    Wilson, W
    Bates, SE
    Fojo, T
    [J]. BLOOD, 1998, 91 (05) : 1749 - 1756
1