New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study

被引：225

作者：

Lu, Lu ^{[1
]}

Xiong, Weixi ^{[1
]}

Liu, Dan ^{[2
]}

Liu, Jing ^{[3
]}

Yang, Dan ^{[3
]}

Li, Nian ^{[4
]}

Mu, Jie ^{[1
]}

Guo, Jian ^{[1
]}

Li, Weimin ^{[2
]}

Wang, Gang ^{[2
]}

Gao, Hui ^{[1
]}

Zhang, Yingying ^{[1
]}

Lin, Mintao ^{[1
]}

Chen, Lei ^{[1
]}

Shen, Sisi ^{[1
]}

Zhang, Hesheng ^{[1
]}

Sander, Josemir W. ^{[5
,6
,7
]}

Luo, Jianfei ^{[8
]}

Chen, Shengli ^{[3
]}

Zhou, Dong ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Pulm & Crit Care Med, Chengdu, Peoples R China

[3] Chongqing Three Gorges Cent Hosp, Dept Neurol, Chongqing, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Med Affairs, Chengdu, Peoples R China

[5] UCL, Biomed Res Ctr, Natl Inst Hlth Res, Univ Coll London Hosp,Inst Neurol, Queen Sq, London, England

[6] Chalfont Ctr Epilepsy, Gerrards Cross, England

[7] Stichting Epilepsie Instellingen Nederland, Heemstede, Netherlands

[8] Wuhan Univ, Dept Gastrointestinal Surg, Renmin Hosp, Wuhan, Peoples R China

来源：

EPILEPSIA | 2020年 / 61卷 / 06期

基金：

中国国家自然科学基金;

关键词：

acute symptomatic seizures; COVID-19; epilepsy; SARS-CoV-2; INFECTION; SARS;

D O I：

10.1111/epi.16524

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID-19). This multicenter retrospective study enrolled people with COVID-19 from January 18 to February 18, 2020 at 42 government-designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had a severe condition. None in this cohort had a known history of epilepsy. Neither acute symptomatic seizures nor status epilepticus was observed. Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. There was no evidence suggesting an additional risk of acute symptomatic seizures in people with COVID-19. Neither the virus nor potential risk factors for seizures seem to be significant risks for the occurrence of acute symptomatic seizures in COVID-19.

引用

页码：E49 / E53

页数：5

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