Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children

被引：5

作者：

Jung, Sungsu ^{[1
]}

Suh, Dong In ^{[2
]}

Lee, So-Yeon ^{[1
]}

Yoon, Jisun ^{[1
]}

Cho, Hyun-Ju ^{[3
]}

Kim, Young-Ho ^{[1
]}

Yang, Song-I ^{[4
]}

Kwon, Ji-Won ^{[5
]}

Jang, Gwang Cheon ^{[6
]}

Sun, Yong Han ^{[7
]}

Woo, Sung-Il ^{[8
]}

Youn, You-Sook ^{[9
]}

Park, Kang Seo ^{[10
]}

Cho, Hwa Jin ^{[11
]}

Kook, Myung-Hee ^{[12
]}

Yi, Hye Ryoung ^{[12
]}

Chung, Hai Lee ^{[13
]}

Kim, Ja Hyeong ^{[14
]}

Kim, Hyung Young ^{[15
]}

Jung, Jin A. ^{[16
]}

Woo, Hyang-Ok ^{[17
]}

Hong, Soo-Jong ^{[1
]}

机构：

[1] Univ Ulsan, Dept Pediat, Childhood Asthma Atopy Ctr, Environm Hlth Ctr,Asan Med Ctr,Coll Med, Seoul, South Korea

[2] Seoul Natl Univ Hosp, Dept Pediat, Seoul, South Korea

[3] Catholic Kwandong Univ Hosp, Int St Marys Hosp, Dept Pediat, Incheon, South Korea

[4] Hallym Univ, Dept Pediat, Sacred Heart Hosp, Anyang, South Korea

[5] Seoul Natl Univ, Dept Pediat, Bundang Hosp, Seongnam, South Korea

[6] Ilsan Hosp, Dept Pediat, Natl Hlth Insurance Serv, Goyang, South Korea

[7] Gachon Univ, Dept Pediat, Gil Med Ctr, Incheon, South Korea

[8] Chungbuk Natl Univ, Dept Pediat, Coll Med, Cheongju, South Korea

[9] Catholic Univ Korea, Dept Pediat, Coll Med, Daejeon, South Korea

[10] Presbyterian Med Ctr, Dept Pediat, Jeonju, South Korea

[11] Chonnam Natl Univ, Med Sch, Dept Pediat, Chonnam Natl Univ Hosp, Gwangju, South Korea

[12] Gwangju Vet Hosp, Dept Pediat, Gwangju, South Korea

[13] Catholic Univ Daegu, Dept Pediat, Sch Med, Daegu, South Korea

[14] Ulsan Univ Hosp, Dept Pediat, Ulsan, South Korea

[15] Pusan Natl Univ, Dept Pediat, Yangsan Hosp, Yangsan, South Korea

[16] Dong A Univ, Dept Pediat, Coll Med, Busan, South Korea

[17] Gyeongsang Natl Univ, Hlth Sci Inst, Dept Pediat, Coll Med, Jinju, South Korea

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2018年 / 10卷 / 5-6期

关键词：

Bronchial hyperreactivity; asthma; risk factors; prevalence; ROC curve; AIRWAY HYPERRESPONSIVENESS; LUNG-FUNCTION; FOLLOW-UP; ASTHMA; METHACHOLINE; RESPONSIVENESS; CHILDHOOD; RHINOCONJUNCTIVITIS; ASSOCIATION; SAPALDIA;

D O I：

10.4168/aair.2018.10.5.466

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine (R)) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate the prevalence, risk factors and cutoff value of bronchial hyperresponsiveness (BHR) to Provocholine in 7-year-old children. Methods: Six hundred and thirty-three children from the Panel Study on Korean Children who visited 16 regional hospitals were evaluated. Skin prick tests, spirometry and bronchial provocation tests for Provocholine as well as a detailed history and physical examinations were performed. The bronchial provocation test was reliably performed on 559 of these children. Results: The prevalence of ever-diagnosed asthma via medical records was 7.7%, and that of current asthma (wheezy episode in the last 12 months + diagnosed asthma by physicians) was 3.2%. The prevalence of BHR to Provocholine was 17.2% and 25.8%, respectively, for a PC20 < 8 and < 16 mg/mL. The risk factors for BHR (PC20 < 16 mg/mL) were atopic dermatitis diagnosis and current dog ownership, whereas those for current asthma were allergy rhinitis diagnosis, a history of bronchiolitis before the age of 3, recent use of analgesics/antipyretics and maternal history of asthma. The BHR prevalence trend showed an increase along with the increased immunoglobulin E (IgE) quartile. The cutoffvalue of PC20 for the diagnosis of current asthma in children at age 7 was 5.8 mg/mL (sensitivity: 47.1%, specificity: 87.4%). Conclusions: BHR to Provocholine (PC20 < 8 mg/mL) was observed in 17.2% of 7-year-olds children from the general population and the cutoff value of PC20 for the diagnosis of current asthma was 5.8 mg/mL in this age group. The risk factors for BHR and current asthma showed discrepancies suggesting different underlying mechanisms. Bronchial provocation testing with Provocholine will be a useful clinical tool in the future.

引用

页码：466 / 477

页数：12

共 32 条

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