Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers

被引：26

作者：

Marck, Roos E. ^{[1
,2
,3
]}

Gardien, Kim L. M. ^{[2
,3
]}

Vlig, Marcel ^{[4
]}

Breederveld, Roelf S. ^{[2
,5
]}

Middelkoop, Esther ^{[2
,3
,4
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Dept Plast Reconstruct & Hand Surg, NL-1081 HV Amsterdam, Netherlands

[2] Red Cross Hosp, Burn Ctr, NL-1942 LE Beverwijk, Netherlands

[3] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Movement Sci Res Inst, Dept Plast Reconstruct & Hand Surg, NL-1081 HV Amsterdam, Netherlands

[4] Assoc Dutch Burn Ctr, NL-1942 LE Beverwijk, Netherlands

[5] Leiden Univ, Med Ctr, Dept Surg, NL-2333 ZA Leiden, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 02期

关键词：

platelets; burns; growth factors; platelet rich plasma; quantification;

D O I：

10.3390/ijms20020288

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. In this study, growth factor quantification measurements of PRP from burn patients and gender- and age-matched controls were performed. The PRP of burn patients showed levels of growth factors comparable to those of the PRP of healthy volunteers. Considerable intra-individual variation in growth factor content was found. However, a correlation was found between the platelet count of the PRP and most of the growth factors measured.

引用

页数：8

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