Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

被引：50

作者：

Al Olama, Ali Amin ^{[1
]}

Benlloch, Sara ^{[1
]}

Antoniou, Antonis C. ^{[1
]}

Giles, Graham G. ^{[2
,3
]}

Severi, Gianluca ^{[2
]}

Neal, David E. ^{[4
,5
]}

Hamdy, Freddie C. ^{[6
,7
]}

Donovan, Jenny L. ^{[8
]}

Muir, Kenneth ^{[9
,10
]}

Schleutker, Johanna ^{[11
,12
,13
]}

Henderson, Brian E. ^{[14
]}

Haiman, Christopher A. ^{[14
]}

Schumacher, Fredrick R. ^{[14
]}

Pashayan, Nora ^{[1
,15
]}

Pharoah, Paul D. P. ^{[1
]}

Ostrander, Elaine A. ^{[16
]}

Stanford, Janet L. ^{[17
,18
]}

Batra, Jyotsna ^{[19
,20
]}

Clements, Judith A. ^{[19
,20
]}

Chambers, Suzanne K. ^{[21
,22
,23
]}

Weischer, Maren ^{[24
]}

Nordestgaard, Borge G. ^{[24
]}

Ingles, Sue A.

Sorensen, Karina D. ^{[25
]}

Orntoft, Torben F. ^{[25
]}

Park, Jong Y. ^{[26
]}

Cybulski, Cezary ^{[27
]}

Maier, Christiane ^{[28
]}

Doerk, Thilo ^{[29
]}

Dickinson, Joanne L. ^{[30
]}

Cannon-Albright, Lisa ^{[31
,32
]}

Brenner, Hermann ^{[33
,34
]}

Rebbeck, Timothy R. ^{[35
]}

Zeigler-Johnson, Charnita ^{[36
]}

Habuchi, Tomonori ^{[37
]}

Thibodeau, Stephen N. ^{[38
]}

Cooney, Kathleen A. ^{[39
]}

Chappuis, Pierre O. ^{[40
,41
]}

Hutter, Pierre ^{[42
]}

Kaneva, Radka P. ^{[43
]}

Foulkes, William D. ^{[44
]}

Zeegers, Maurice P. ^{[45
]}

Lu, Yong-Jie ^{[46
]}

Zhang, Hong-Wei ^{[47
]}

Stephenson, Robert ^{[48
]}

Cox, Angela ^{[49
]}

Southey, Melissa C. ^{[50
]}

Spurdle, Amanda B. ^{[51
]}

FitzGerald, Liesel ^{[52
]}

Leongamornlert, Daniel ^{[53
]}

机构：

[1] Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Cambridge, England

[2] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia

[3] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[4] Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England

[5] Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge, England

[6] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England

[7] Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford OX3 9DU, England

[8] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England

[9] Univ Manchester, Ctr Epidemiol, Inst Populat Hlth, Manchester, Lancs, England

[10] Univ Warwick, Coventry CV4 7AL, W Midlands, England

[11] Univ Tampere, Inst Biomed Technol, BioMediTech, FIN-33101 Tampere, Finland

[12] FimLab Labs, Tampere, Finland

[13] Univ Turku, Dept Med Biochem & Genet, Turku, Finland

[14] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA

[15] UCL, Dept Appl Hlth Res, London, England

[16] NHGRI, NIH, Bethesda, MD 20892 USA

[17] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[18] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[19] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Australian Prostate Canc Res Ctr Qld, Brisbane, Qld 4001, Australia

[20] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia

[21] Griffith Univ, Griffith Hlth Inst, Gold Coast, Qld, Australia

[22] Canc Council Queensland, Brisbane, Qld, Australia

[23] Prostate Canc Fdn Australia, Sydney, NSW, Australia

[24] Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, Herlev, Denmark

[25] Aarhus Univ Hosp, Dept Mol Med MOMA, Aarhus N, Denmark

[26] Univ S Florida, H Lee Moffitt Canc Ctr, Div Canc Prevent & Control, Tampa, FL 33682 USA

[27] Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland

[28] Univ Hosp Ulm, Dept Urol, Ulm, Germany

[29] Hannover Biomed Res Sch, Hannover, Germany

[30] Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas, Australia

[31] Univ Utah, Sch Med, Dept Med, Div Genet Epidemiol, Salt Lake City, UT USA

[32] George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT USA

[33] German Canc Res Ctr, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany

[34] German Canc Consortium DKTK, Heidelberg, Germany

[35] Univ Penn, Philadelphia, PA 19104 USA

[36] Thomas Jefferson Univ, Dept Med Oncol, Div Populat Sci, Philadelphia, PA 19107 USA

[37] Akita Univ, Sch Med, Dept Urol, Akita 010, Japan

[38] Mayo Clin, Rochester, MN USA

[39] Univ Michigan, Sch Med, Div Hematol Oncol, Ann Arbor, MI USA

[40] Univ Hosp Geneva, Div Oncol Med, Geneva, Switzerland

[41] Univ Hosp Geneva, Dept Med Genet, Geneva, Switzerland

[42] Univ Geneva, Hop Cantonal, CH-1211 Geneva, Switzerland

[43] Med Univ Sofia, Mol Med Ctr, Dept Med Chem & Biochem, Sofia, Bulgaria

[44] McGill Univ, Montreal, PQ, Canada

[45] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Complex Genet,Cluster Genet & Cell Biol, NL-6200 MD Maastricht, Netherlands

[46] Queen Mary Univ London, John Vane Sci Ctr, Barts Canc Inst, London, England

[47] Second Mil Med Univ, Shanghai, Peoples R China

[48] Univ Utah, Sch Med, Dept Surg, Div Urol, Salt Lake City, UT USA

[49] Univ Sheffield, CR UK YCR Sheffield Canc Res Ctr, Sheffield, S Yorkshire, England

[50] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2015年 / 24卷 / 07期

关键词：

GENOME-WIDE ASSOCIATION; BREAST-CANCER; MULTIPLE LOCI; PREDICTION; VARIANTS; IDENTIFICATION; BRCA2;

D O I：

10.1158/1055-9965.EPI-14-0317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their risk of prostate cancer. Methods: We genotyped 25 prostate cancer susceptibility loci in 40,414 individuals and derived a polygenic risk score (PRS). We estimated empirical odds ratios (OR) for prostate cancer associated with different risk strata defined by PRS and derived age-specific absolute risks of developing prostate cancer by PRS stratum and family history. Results: The prostate cancer risk for men in the top 1% of the PRS distribution was 30.6 (95% CI, 16.4-57.3) fold compared with men in the bottom 1%, and 4.2 (95% CI, 3.2-5.5) fold compared with the median risk. The absolute risk of prostate cancer by age of 85 years was 65.8% for a man with family history in the top 1% of the PRS distribution, compared with 3.7% for a man in the bottom 1%. The PRS was only weakly correlated with serum PSA level (correlation = 0.09). Conclusions: Risk profiling can identify men at substantially increased or reduced risk of prostate cancer. The effect size, measured by OR per unit PRS, was higher in men at younger ages and in men with family history of prostate cancer. Incorporating additional newly identified loci into a PRS should improve the predictive value of risk profiles. Impact: We demonstrate that the risk profiling based on SNPs can identify men at substantially increased or reduced risk that could have useful implications for targeted prevention and screening programs. (C) 2015 AACR.

引用

页码：1121 / 1129

页数：9

共 22 条

[1] A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Berndt, Sonja I. ;

Conti, David V. ;

Schumacher, Fredrick ;

Han, Ying ;

Benlloch, Sara ;

Hazelett, Dennis J. ;

Wang, Zhaoming ;

Saunders, Ed ;

Leongamornlert, Daniel ;

Lindstrom, Sara ;

Jugurnauth-Little, Sara ;

Dadaev, Tokhir ;

Tymrakiewicz, Malgorzata ;

Stram, Daniel O. ;

Rand, Kristin ;

Wan, Peggy ;

Stram, Alex ;

Sheng, Xin ;

Pooler, Loreall C. ;

Park, Karen ;

Xia, Lucy ;

Tyrer, Jonathan ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Hoover, Robert N. ;

Machiela, Mitchell J. ;

Yeager, Merideth ;

Burdette, Laurie ;

Chung, Charles C. ;

Hutchinson, Amy ;

Yu, Kai ;

Goh, Chee ;

Ahmed, Mahbubl ;

Govindasami, Koveela ;

Guy, Michelle ;

Tammela, Teuvo L. J. ;

Auvinen, Anssi ;

Wahlfors, Tlina ;

Schleutker, Johanna ;

Visakorpi, Tapio ;

Leinonen, Katri A. ;

Xu, Jianfeng ;

Aly, Markus ;

Donovan, Jenny ;

Travis, Ruth C. ;

Key, Tim J. ;

Siddiq, Afshan ;

Canzian, Federico .

NATURE GENETICS, 2014, 46 (10) :1103-1109

[2] Multiple loci on 8q24 associated with prostate cancer susceptibility [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Guy, Michelle ;

Morrison, Jonathan ;

Severi, Gianluca ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Jhavar, Sameer ;

Saunders, Ed ;

Hopper, John L. ;

Southey, Melissa C. ;

Muir, Kenneth R. ;

English, Dallas R. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Sawyer, Emma ;

Lophatananon, Artitaya ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Cooper, Colin ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Neal, David E. ;

Eeles, Rosalind A. ;

Easton, Douglas F. .

NATURE GENETICS, 2009, 41 (10) :1058-1060

[3] Polygenic Risk Score Improves Prostate Cancer Risk Prediction: Results from the Stockholm-1 Cohort Study [J].

Aly, Markus ;

Wiklund, Fredrik ;

Xu, Jianfeng ;

Isaacs, William B. ;

Eklund, Martin ;

D'Amato, Mauro ;

Adolfsson, Jan ;

Gronberg, Henrik .

EUROPEAN UROLOGY, 2011, 60 (01) :21-28

[4] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[5] Polygenic inheritance of breast cancer: Implications for design of association studies [J].

Antoniou, AC ;

Easton, DF .

GENETIC EPIDEMIOLOGY, 2003, 25 (03) :190-202

[6] Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study [J].

Antoniou, AC ;

Pharoah, PDP ;

McMullan, G ;

Day, NE ;

Ponder, BAJ ;

Easton, D .

GENETIC EPIDEMIOLOGY, 2001, 21 (01) :1-18

[7] Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction [J].

Antoniou, Antonis C. ;

Beesley, Jonathan ;

McGuffog, Lesley ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Neuhausen, Susan L. ;

Ding, Yuan Chun ;

Rebbeck, Timothy R. ;

Weitzel, Jeffrey N. ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Ganz, Patricia A. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Couch, Fergus J. ;

Wang, Xianshu ;

Lindor, Noralane M. ;

Pankratz, Vernon S. ;

Radice, Paolo ;

Manoukian, Siranoush ;

Peissel, Bernard ;

Zaffaroni, Daniela ;

Barile, Monica ;

Viel, Alessandra ;

Allavena, Anna ;

Dall'Olio, Valentina ;

Peterlongo, Paolo ;

Szabo, Csilla I. ;

Zikan, Michal ;

Claes, Kathleen ;

Poppe, Bruce ;

Foretova, Lenka ;

Mai, Phuong L. ;

Greene, Mark H. ;

Rennert, Gad ;

Lejbkowicz, Flavio ;

Glendon, Gord ;

Ozcelik, Hilmi ;

Andrulis, Irene L. ;

Thomassen, Mads ;

Gerdes, Anne-Marie ;

Sunde, Lone ;

Cruger, Dorthe ;

Jensen, Uffe Birk ;

Caligo, Maria ;

Friedman, Eitan ;

Kaufman, Bella ;

Laitman, Yael ;

Milgrom, Roni ;

Dubrovsky, Maya .

CANCER RESEARCH, 2010, 70 (23) :9742-9754

[8] Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies [J].

Chatterjee, Nilanjan ;

Wheeler, Bill ;

Sampson, Joshua ;

Hartge, Patricia ;

Chanock, Stephen J. ;

Park, Ju-Hyun .

NATURE GENETICS, 2013, 45 (04) :400-405

[9] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[10] Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array [J].

Eeles, Rosalind A. ;

Al Olama, Ali Amin ;

Benlloch, Sara ;

Saunders, Edward J. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Ghoussaini, Maya ;

Luccarini, Craig ;

Dennis, Joe ;

Jugurnauth-Little, Sarah ;

Dadaev, Tokhir ;

Neal, David E. ;

Hamdy, Freddie C. ;

Donovan, Jenny L. ;

Muir, Ken ;

Giles, Graham G. ;

Severi, Gianluca ;

Wiklund, Fredrik ;

Gronberg, Henrik ;

Haiman, Christopher A. ;

Schumacher, Fredrick ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Lindstrom, Sara ;

Kraft, Peter ;

Hunter, David J. ;

Gapstur, Susan ;

Chanock, Stephen J. ;

Berndt, Sonja I. ;

Albanes, Demetrius ;

Andriole, Gerald ;

Schleutker, Johanna ;

Weischer, Maren ;

Canzian, Federico ;

Riboli, Elio ;

Key, Tim J. ;

Travis, Ruth C. ;

Campa, Daniele ;

Ingles, Sue A. ;

John, Esther M. ;

Hayes, Richard B. ;

Pharoah, Paul D. P. ;

Pashayan, Nora ;

Khaw, Kay-Tee ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Signorello, Lisa B. ;

Thibodeau, Stephen N. ;

Schaid, Dan ;

Maier, Christiane .

NATURE GENETICS, 2013, 45 (04) :385-391

← 1 2 3 →

共 22 条

[1] A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Berndt, Sonja I. ;

Conti, David V. ;

Schumacher, Fredrick ;

Han, Ying ;

Benlloch, Sara ;

Hazelett, Dennis J. ;

Wang, Zhaoming ;

Saunders, Ed ;

Leongamornlert, Daniel ;

Lindstrom, Sara ;

Jugurnauth-Little, Sara ;

Dadaev, Tokhir ;

Tymrakiewicz, Malgorzata ;

Stram, Daniel O. ;

Rand, Kristin ;

Wan, Peggy ;

Stram, Alex ;

Sheng, Xin ;

Pooler, Loreall C. ;

Park, Karen ;

Xia, Lucy ;

Tyrer, Jonathan ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Hoover, Robert N. ;

Machiela, Mitchell J. ;

Yeager, Merideth ;

Burdette, Laurie ;

Chung, Charles C. ;

Hutchinson, Amy ;

Yu, Kai ;

Goh, Chee ;

Ahmed, Mahbubl ;

Govindasami, Koveela ;

Guy, Michelle ;

Tammela, Teuvo L. J. ;

Auvinen, Anssi ;

Wahlfors, Tlina ;

Schleutker, Johanna ;

Visakorpi, Tapio ;

Leinonen, Katri A. ;

Xu, Jianfeng ;

Aly, Markus ;

Donovan, Jenny ;

Travis, Ruth C. ;

Key, Tim J. ;

Siddiq, Afshan ;

Canzian, Federico .

NATURE GENETICS, 2014, 46 (10) :1103-1109

[2] Multiple loci on 8q24 associated with prostate cancer susceptibility [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Guy, Michelle ;

Morrison, Jonathan ;

Severi, Gianluca ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Jhavar, Sameer ;

Saunders, Ed ;

Hopper, John L. ;

Southey, Melissa C. ;

Muir, Kenneth R. ;

English, Dallas R. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Sawyer, Emma ;

Lophatananon, Artitaya ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Cooper, Colin ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Neal, David E. ;

Eeles, Rosalind A. ;

Easton, Douglas F. .

NATURE GENETICS, 2009, 41 (10) :1058-1060

[3] Polygenic Risk Score Improves Prostate Cancer Risk Prediction: Results from the Stockholm-1 Cohort Study [J].

Aly, Markus ;

Wiklund, Fredrik ;

Xu, Jianfeng ;

Isaacs, William B. ;

Eklund, Martin ;

D'Amato, Mauro ;

Adolfsson, Jan ;

Gronberg, Henrik .

EUROPEAN UROLOGY, 2011, 60 (01) :21-28

[4] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[5] Polygenic inheritance of breast cancer: Implications for design of association studies [J].

Antoniou, AC ;

Easton, DF .

GENETIC EPIDEMIOLOGY, 2003, 25 (03) :190-202

[6] Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study [J].

Antoniou, AC ;

Pharoah, PDP ;

McMullan, G ;

Day, NE ;

Ponder, BAJ ;

Easton, D .

GENETIC EPIDEMIOLOGY, 2001, 21 (01) :1-18

[7] Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction [J].

Antoniou, Antonis C. ;

Beesley, Jonathan ;

McGuffog, Lesley ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Neuhausen, Susan L. ;

Ding, Yuan Chun ;

Rebbeck, Timothy R. ;

Weitzel, Jeffrey N. ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Ganz, Patricia A. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Couch, Fergus J. ;

Wang, Xianshu ;

Lindor, Noralane M. ;

Pankratz, Vernon S. ;

Radice, Paolo ;

Manoukian, Siranoush ;

Peissel, Bernard ;

Zaffaroni, Daniela ;

Barile, Monica ;

Viel, Alessandra ;

Allavena, Anna ;

Dall'Olio, Valentina ;

Peterlongo, Paolo ;

Szabo, Csilla I. ;

Zikan, Michal ;

Claes, Kathleen ;

Poppe, Bruce ;

Foretova, Lenka ;

Mai, Phuong L. ;

Greene, Mark H. ;

Rennert, Gad ;

Lejbkowicz, Flavio ;

Glendon, Gord ;

Ozcelik, Hilmi ;

Andrulis, Irene L. ;

Thomassen, Mads ;

Gerdes, Anne-Marie ;

Sunde, Lone ;

Cruger, Dorthe ;

Jensen, Uffe Birk ;

Caligo, Maria ;

Friedman, Eitan ;

Kaufman, Bella ;

Laitman, Yael ;

Milgrom, Roni ;

Dubrovsky, Maya .

CANCER RESEARCH, 2010, 70 (23) :9742-9754

[8] Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies [J].

Chatterjee, Nilanjan ;

Wheeler, Bill ;

Sampson, Joshua ;

Hartge, Patricia ;

Chanock, Stephen J. ;

Park, Ju-Hyun .

NATURE GENETICS, 2013, 45 (04) :400-405

[9] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[10] Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array [J].

Eeles, Rosalind A. ;

Al Olama, Ali Amin ;

Benlloch, Sara ;

Saunders, Edward J. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Ghoussaini, Maya ;

Luccarini, Craig ;

Dennis, Joe ;

Jugurnauth-Little, Sarah ;

Dadaev, Tokhir ;

Neal, David E. ;

Hamdy, Freddie C. ;

Donovan, Jenny L. ;

Muir, Ken ;

Giles, Graham G. ;

Severi, Gianluca ;

Wiklund, Fredrik ;

Gronberg, Henrik ;

Haiman, Christopher A. ;

Schumacher, Fredrick ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Lindstrom, Sara ;

Kraft, Peter ;

Hunter, David J. ;

Gapstur, Susan ;

Chanock, Stephen J. ;

Berndt, Sonja I. ;

Albanes, Demetrius ;

Andriole, Gerald ;

Schleutker, Johanna ;

Weischer, Maren ;

Canzian, Federico ;

Riboli, Elio ;

Key, Tim J. ;

Travis, Ruth C. ;

Campa, Daniele ;

Ingles, Sue A. ;

John, Esther M. ;

Hayes, Richard B. ;

Pharoah, Paul D. P. ;

Pashayan, Nora ;

Khaw, Kay-Tee ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Signorello, Lisa B. ;

Thibodeau, Stephen N. ;

Schaid, Dan ;

Maier, Christiane .

NATURE GENETICS, 2013, 45 (04) :385-391

← 1 2 3 →