Cell-based carrier for targeted hitchhiking delivery

被引:16
作者
Liu, Tonggong [1 ,2 ]
Gao, Cheng [2 ,3 ]
Gu, Dayong [2 ]
Tang, Huanwen [1 ]
机构
[1] Guangdong Med Univ, Sch Publ Hlth, Dept Prevent Med, Dongguan Key Lab Environm Med, Dongguan 523808, Peoples R China
[2] Shenzhen Univ, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med, Dept Lab Med,Affiliated Hosp 1, Shenzhen 518035, Peoples R China
[3] Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Cell-based carrier; Drug delivery system; Construct; Clinical translation; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY; HUMAN ERYTHROCYTES; IN-VITRO; NANOPARTICLES; CIRCULATION; PLATELETS; SYSTEMS; ELECTROPORATION; DEHYDROGENASE;
D O I
10.1007/s13346-022-01149-y
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Drug delivery systems aim at improving drug transport efficiency and therapeutic efficacy by rational design, and current research on conventional delivery systems brings new developments for disease treatment. Recently, studies on cell-based drug delivery systems are rapidly emerging, which shows great advantages in comparison to conventional drug delivery system. The system uses cells as carriers to delivery conventional drugs or nanomedicines and shows good biocompatibility and enhanced targeting efficiency, beneficial from self component and its physiological function. The construction methodology of cell-based carrier determines the effect on the physiological functions of transporting cell and affects its clinical application. There are different strategies to prepare cell-based carrier, such as direct internalization or surface conjugation of drugs or drug loaded materials. Thus, it is necessary to fully understand the advantages and disadvantages of different strategies for constructing cell-based carrier and then to seek the appropriate construction methodology for achieving better therapeutic results based on disease characterization. We here summarize the application of different types of cell-based carriers reported in recent years and further discuss their applications in disease therapy and the dilemmas faced in clinical translation. We hope that this summary can accelerate the process of clinical translation by promoting the technology development of cell-based carrier.
引用
收藏
页码:2634 / 2648
页数:15
相关论文
共 96 条
  • [1] High-Throughput and Dosage-Controlled Intracellular Delivery of Large Cargos by an Acoustic-Electric Micro-Vortices Platform
    Aghaamoo, Mohammad
    Chen, Yu-Hsi
    Li, Xuan
    Garg, Neha
    Jiang, Ruoyu
    Yun, Jeremy Tian-Hao
    Lee, Abraham Phillip
    [J]. ADVANCED SCIENCE, 2022, 9 (01)
  • [2] Entering the Modern Era of Gene Therapy
    Anguela, Xavier M.
    High, Katherine A.
    [J]. ANNUAL REVIEW OF MEDICINE, VOL 70, 2019, 70 : 273 - 288
  • [3] Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells
    Anselmo, Aaron C.
    Gupta, Vivek
    Zern, Blaine J.
    Pan, Daniel
    Zakrewsky, Michael
    Muzykantov, Vladimir
    Mitragotri, Samir
    [J]. ACS NANO, 2013, 7 (12) : 11129 - 11137
  • [4] Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases
    Asil, Shima Masoudi
    Ahlawat, Jyoti
    Barroso, Gileydis Guillama
    Narayan, Mahesh
    [J]. BIOMATERIALS SCIENCE, 2020, 8 (15) : 4109 - 4128
  • [5] DRUG-INDUCED ERYTHROCYTE-MEMBRANE INTERNALIZATION
    BENBASSAT, I
    BENSCH, KG
    SCHRIER, SL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (07) : 1833 - +
  • [6] Human CD14+cells loaded with Paclitaxel inhibit in vitro cell proliferation of glioblastoma
    Bonomi, Arianna
    Lisini, Daniela
    Navone, Stefania Elena
    Frigerio, Simona
    Dossena, Marta
    Ciusani, Emilio
    Rampini, Paolo
    Marfia, Giovanni
    Cocce, Valentina
    Cavicchini, Loredana
    Sisto, Francesca
    Parati, Eugenio
    Mantegazza, Renato
    Rimoldi, Marco
    Rizzetto, Manuela
    Alessandri, Giulio
    Pessina, Augusto
    [J]. CYTOTHERAPY, 2015, 17 (03) : 310 - 319
  • [7] Exploiting dendritic cells for cancer immunotherapy: genetic modification of dendritic cells
    Breckpot, K
    Heirman, C
    Neyns, B
    Thielemans, K
    [J]. JOURNAL OF GENE MEDICINE, 2004, 6 (11) : 1175 - 1188
  • [8] Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
    Brenner, Jacob S.
    Pan, Daniel C.
    Myerson, Jacob W.
    Marcos-Contreras, Oscar A.
    Villa, Carlos H.
    Patel, Priyal
    Hekierski, Hugh
    Chatterjee, Shampa
    Tao, Jian-Qin
    Parhiz, Hamideh
    Bhamidipati, Kartik
    Uhler, Thomas G.
    Hood, Elizabeth D.
    Kiseleva, Raisa Yu.
    Shuvaev, Vladimir S.
    Shuvaeva, Tea
    Khoshnejad, Makan
    Johnston, Ian
    Gregory, Jason V.
    Lahann, Joerg
    Wang, Tao
    Cantu, Edward
    Armstead, William M.
    Mitragotri, Samir
    Muzykantov, Vladimir
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [9] The Ins and Outs of Messenger RNA Electroporation for Physical Gene Delivery in Immune Cell-Based Therapy
    Campillo-Davo, Diana
    De Laere, Maxime
    Roex, Gils
    Versteven, Maarten
    Flumens, Donovan
    Berneman, Zwi N.
    Van Tendeloo, Viggo F. I.
    Anguille, Sebastien
    Lion, Eva
    [J]. PHARMACEUTICS, 2021, 13 (03)
  • [10] Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes
    Chambers, E
    Mitragotri, S
    [J]. JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) : 111 - 119