Some markers of neuronal damage in cerebrospinal fluid of multiple sclerosis patients in relapse

被引：0
|
作者：
Mitosek-Szewczyk, Krystyna [1 ,2 ]
Gordon-Krajcer, Wanda [3 ]
Flis, Dorota [4 ]
Stelmasiak, Zbigniew [1 ]
机构：
[1] Med Univ Lublin, Dept Neurol, PL-20954 Lublin, Poland
[2] Med Univ Lublin, Dept Child Neurol, PL-20954 Lublin, Poland
[3] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland
[4] Publ Independent Clin Hosp 4 Lublin, Lublin, Poland
来源：
FOLIA NEUROPATHOLOGICA | 2011年 / 49卷 / 03期
关键词：
multiple sclerosis; neurofilament; tau and phospho-tau proteins; S-100B; beta-APP; A beta-amyloid protein; neuron-specific enolase; AMYLOID PRECURSOR PROTEIN; MYELIN BASIC-PROTEIN; NEUROFILAMENT PROTEIN; CEREBRAL-ISCHEMIA; AXONAL DAMAGE; TAU; ACCUMULATION; BRAIN; S-100; EXPRESSION;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this paper the performance of cerebrospinal fluid (CSF) protein biomarkers important for monitoring damage of brain astrocytes and neurons for MS is reviewed. We estimated neurofilament, tau and phospho-tau proteins, beta-APP, A beta, S-100B and neuron-specific enolase in CSF of MS patients during relapse. We noted elevation of neurofilament, tau and phospho-tau proteins, S-100B, neuron-specific enolase and c-terminal epitopes of beta-APP; concomitantly decrease of A beta was observed. These CSF biomarkers for MS relapse should reflect the central pathogenic processes in the brain, i.e., axonal and neuronal degeneration.
引用
收藏
页码：191 / 196
页数：6
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