Long-term follow-up experience with adjuvant therapy after irreversible electroporation of locally advanced pancreatic cancer

被引:3
作者
Thomas, Alexander S. [1 ]
Kwon, Wooil [1 ,2 ,3 ]
Horowitz, David P. [4 ]
Bates, Susan E. [5 ]
Fojo, Antonio T. [5 ]
Manji, Gulam A. [5 ]
Schreibman, Stephen [5 ]
Schrope, Beth A. [1 ]
Chabot, John A. [1 ]
Kluger, Michael D. [1 ]
机构
[1] Columbia Univ, Dept Surg, Div Gastrointestinal & Endocrine Surg, Irving Med Ctr, New York, NY USA
[2] Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea
[3] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea
[4] Columbia Univ Irving Med New York, Herbert Irving Comprehens Canc Ctr, Dept Radiat Oncol, New York, NY USA
[5] Columbia Univ, Div Hematol & Oncol, Irving Med Ctr, New York, NY USA
关键词
adjuvant chemotherapy for pancreatic adenocarcinoma; irreversible electroporation; locally advanced pancreatic adenocarcinoma; SINGLE-INSTITUTION EXPERIENCE; PHASE-III; ADENOCARCINOMA; CHEMORADIOTHERAPY; CHEMOTHERAPY; GEMCITABINE; SAFETY; MANAGEMENT; CARCINOMA; RESECTION;
D O I
10.1002/jso.27085
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Irreversible electroporation (IRE) expands the surgical options for patients with unresectable pancreatic cancer. This study evaluated for differences in survival stratified by type of IRE and receipt of adjuvant chemotherapy. Methods Patients with locally advanced pancreatic cancer treated by IRE (2012-2020) were retrospectively included. Overall survival (OS) and recurrence-free survival (RFS) were compared by type of IRE (in situ for local tumor control or IRE of potentially positive margins with resection) and by receipt of adjuvant chemotherapy. Results Thirty-nine patients had IRE in situ, 61 had IRE for margin extension, and 19 received adjuvant chemotherapy. Most (97.00%) underwent induction chemotherapy. OS was 28.71 months (interquartile range [IQR] 19.17, 51.19) from diagnosis, with no difference by IRE type (hazard ratio [HR] 1.05 for margin extension [p = 0.85]) or adjuvant chemotherapy (HR 1.14 [p = 0.639]). RFS was 8.51 months (IQR 4.95, 20.17) with no difference by IRE type (HR 0.90 for margin extension [p = 0.694]) or adjuvant chemotherapy (HR 0.90 [p = 0.711]). Conclusion These findings suggest that adjuvant therapy may have limited benefit for patients treated with induction chemotherapy followed by local control with IRE for unresectable pancreatic cancer. Further study of the duration and timing of systemic therapy is warranted to maximize benefit and limit toxicity.
引用
收藏
页码:1442 / 1450
页数:9
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