Malignancy incidence in patients with psoriatic arthritis: a comparison cohort-based incidence study

被引：30

作者：

Wilton, Katelynn M. ^{[1
]}

Crowson, Cynthia S. ^{[2
,3
]}

Matteson, Eric L. ^{[2
,3
]}

机构：

[1] Mayo Clin Coll Med, Rochester, MN USA

[2] Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin Coll Med, Div Rheumatol, 200 First St. SW,Rochester, Rochester, MN 55905 USA

来源：

CLINICAL RHEUMATOLOGY | 2016年 / 35卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Epidemiology; Malignancy; Psoriatic arthritis; Spondyloarthropathies; RHEUMATOID-ARTHRITIS; ANKYLOSING-SPONDYLITIS; RISK; POPULATION; LYMPHOMA; EPIDEMIOLOGY; THERAPY; TIME;

D O I：

10.1007/s10067-016-3396-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Malignancy is a major cause of death in patients with inflammatory disease. The risk of individual malignancies is altered in some inflammatory diseases, such as rheumatoid arthritis and psoriasis. This study aimed to examine malignancy incidence in patients with psoriatic arthritis (PsA), a related inflammatory disease. Institutional cancer registry and medical record linkage systems were retrospectively reviewed in a population-based incidence cohort of 217 patients with PsA and 434 age- and sex-matched comparators. Malignancy rates were compared using adjusted Cox models. Incidence of overall malignancy (excluding NMSC; hazard ratio (HR) 1.64; 95 % confidence interval (CI) 1.03-2.61) and breast cancer (HR 3.59; 95 % CI 1.22-10.61), but not NMSC (HR 1.23; 95 % CI 0.72-2.09), were significantly elevated in the PsA cohort. Age and female sex were similar predisposing risk factors in both cohorts. The overall incidence of malignancy, as well as the risk of breast cancer, was higher in patients with PsA than in the general population.

引用

页码：2603 / 2607

页数：5

共 15 条

[1] The risk of infection and malignancy with tumor necrosis factor antagonists in adults with psoriatic disease: A systematic review and meta-analysis of randomized controlled trials [J].

Dommasch, Erica D. ;

Abuabara, Katrina ;

Shin, Daniel B. ;

Josephine Nguyen ;

Troxel, Andrea B. ;

Gelfand, Joel M. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2011, 64 (06) :1035-1050

[2] Cardiovascular Risk Profile at the Onset of Psoriatic Arthritis: A Population-Based Cohort Study [J].

Ernste, F. C. ;

Sanchez-Menendez, M. ;

Wilton, K. M. ;

Crowson, C. S. ;

Matteson, E. L. ;

Kremers, H. Maradit .

ARTHRITIS CARE & RESEARCH, 2015, 67 (07) :1015-1021

[3] Risk of malignancy in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis under immunosuppressive therapy: a single-center experience [J].

Fanto, Marta ;

Peragallo, Mario Stefano ;

Pietrosanti, Mario ;

Di Rosa, Roberta ;

Diamanti, Andrea Picchianti ;

Salemi, Simonetta ;

D'Amelio, Raffaele .

INTERNAL AND EMERGENCY MEDICINE, 2016, 11 (01) :31-40

[4]

Frentz G, 1999, BRIT J DERMATOL, V140, P237

[5] The risk of lymphoma in patients with psoriasis [J].

Gelfand, Joel M. ;

Shin, Daniel B. ;

Neimann, Andrea L. ;

Wang, Xingmei ;

Margolis, David J. ;

Troxel, Andrea B. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (10) :2194-2201

[6]

Gladman DD, 2008, CLIN EXP RHEUMATOL, V26, pS62

[7]

Gooley TA, 1999, STAT MED, V18, P695, DOI 10.1002/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO

[8]

2-O

[9] Ankylosing Spondylitis, Psoriatic Arthritis, and Risk of Malignant Lymphoma A Cohort Study Based on Nationwide Prospectively Recorded Data From Sweden [J].

Hellgren, K. ;

Smedby, K. E. ;

Backlin, C. ;

Sundstrom, C. ;

Feltelius, N. ;

Eriksson, J. K. ;

Baecklund, E. ;

Askling, J. .

ARTHRITIS & RHEUMATOLOGY, 2014, 66 (05) :1282-1290

[10] Prevalence of malignancy in psoriatic arthritis [J].

Rohekar, Sherry ;

Tom, Brian D. M. ;

Hassa, Agnes ;

Schentag, Cathy T. ;

Farewell, Vernon T. ;

Gladman, Dafna D. .

ARTHRITIS AND RHEUMATISM, 2008, 58 (01) :82-87

← 1 2 →