Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts

被引：251

作者：

Espay, Alberto J. ^{[1
,2
]}

Morgante, Francesca ^{[3
]}

Merola, Aristide ^{[1
,2
]}

Fasano, Alfonso ^{[4
,5
]}

Marsili, Luca ^{[1
,2
]}

Fox, Susan H. ^{[4
,5
]}

Bezard, Erwan ^{[6
,7
]}

Picconi, Barbara ^{[8
]}

Calabresi, Paolo ^{[9
]}

Lang, Anthony E. ^{[4
,5
]}

机构：

[1] Univ Cincinnati, UC Gardner Neurosci Inst, 260 Stetson St,Suite 2300, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Gardner Family Ctr Parkinsons Dis & Movement Diso, Dept Neurol, 260 Stetson St,Suite 2300, Cincinnati, OH 45267 USA

[3] St Georges Univ London, Inst Mol & Clin Sci, London, England

[4] Univ Toronto, Edmond J Safra Program Parkinsons Dis, Morton & Gloria Shulman Movement Disorders Clin, Toronto Western Hosp,Univ Hlth Network,Div Neurol, Toronto, ON, Canada

[5] Krembil Brain Inst, Toronto, ON, Canada

[6] Univ Bordeaux, Inst Neurodegenerat Dis, Bordeaux, France

[7] Natl Ctr Sci Res, Inst Neurodegenerat Dis, Bordeaux, France

[8] Univ San Raffaele, IRCCS Univ San Raffaele Pisana, Expt Neurophysiol Lab, Rome, Italy

[9] Univ Perugia, Santa Maria della Misericordia Hosp, Neurol Clin, Perugia, Italy

来源：

ANNALS OF NEUROLOGY | 2018年 / 84卷 / 06期

关键词：

DOPA-INDUCED DYSKINESIA; DEEP BRAIN-STIMULATION; ALLOSTERIC MODULATOR DIPRAGLURANT; STRIATAL CHOLINERGIC INTERNEURONS; CARBIDOPA INTESTINAL GEL; GANGLIA OUTPUT NEURONS; BASAL GANGLIA; DOUBLE-BLIND; ANTIPARKINSONIAN RESPONSE; MOTOR COMPLICATIONS;

D O I：

10.1002/ana.25364

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Levodopa-induced dyskinesia is a common complication in Parkinson disease. Pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa-to-dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal glutamatergic transmission, and overstimulation of nicotinic acetylcholine receptors on dopamine-releasing axons. Delay in initiating levodopa is no longer recommended, as dyskinesia development is a function of disease duration rather than cumulative levodopa exposure. We review current and in-development treatments for peak-dose dyskinesia but suggest that improvements in levodopa delivery alone may reduce its future prevalence.

引用

页码：797 / 811

页数：15

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