LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma

被引：11
作者：
Mang, Wei [1 ,2 ]
Han, Lei [1 ]
Xing, Peng [1 ]
Liu, Bailiang [1 ]
Sun, Zhongqi [1 ]
Zhou, Wenping [1 ]
Dong, Jiahong [3 ]
机构：
[1] Gen Hosp Northern Theater Command, Dept Hepatobiliary Surg, 83 Wenhua Rd, Shenyang 110016, Peoples R China
[2] Gen Hosp Northern Theater Command, Postdoctoral Stn, 83 Wenhua Rd, Shenyang 110016, Peoples R China
[3] Tsinghua Univ, Beijing Tsinghua Changgung Hosp BTCH, Sch Clin Med, Dept Hepatobiliary & Pancreas Surg, Beijing, Peoples R China
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2020年 / 393卷 / 12期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
lncRNA RHPN1-AS1; miR-485-5p; Proliferation; Metastasis; Hepatocellular carcinoma; METASTASIS; METABOLISM; PATHWAY; CELLS;
D O I：
10.1007/s00210-020-01889-z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
It is reported that long noncoding RNA RHPN1-AS1 (lncRNA RHPN1-AS1) functions as an oncogene among multiple types of cancers; however, the effect of lncRNA RHPN1-AS1 in hepatocellular carcinoma (HCC) is left to be investigated. The main purpose of this work was to study the effects of lncRNA RHPN1-AS1/miR-485-5p system on proliferation, migration, and invasion in HCC and future investigate the latent mechanisms. Our work found that lncRNA RHPN1-AS1 was observably up-regulated in HCC tissues and cell lines, especially HCCLM3 and SMMC-7721 cells. LncRNA RHPN1-AS1 knockdown decreased the capacity of proliferation, invasion, and migration in HCCLM3 and SMMC-7721 cells, which could be crippled by miR-485-5p inhibitor. Besides, the expression of basigin (BSG) was decreased after lncRNA RHPN1-AS1 silence, indicating the function of lncRNA RHPN1-AS1/miR-485-5p/BSG axis in HCC progression. Our study opens novel insights to help understand the mechanisms of lncRNA RHPN1-AS1/miR-485-5p/BSG axis in HCC progression, which may provide a new therapeutic target for HCC treatment.
引用
收藏
页码：2543 / 2551
页数：9
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