LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma

被引：10
作者：
Mang, Wei [1 ,2 ]
Han, Lei [1 ]
Xing, Peng [1 ]
Liu, Bailiang [1 ]
Sun, Zhongqi [1 ]
Zhou, Wenping [1 ]
Dong, Jiahong [3 ]
机构：
[1] Gen Hosp Northern Theater Command, Dept Hepatobiliary Surg, 83 Wenhua Rd, Shenyang 110016, Peoples R China
[2] Gen Hosp Northern Theater Command, Postdoctoral Stn, 83 Wenhua Rd, Shenyang 110016, Peoples R China
[3] Tsinghua Univ, Beijing Tsinghua Changgung Hosp BTCH, Sch Clin Med, Dept Hepatobiliary & Pancreas Surg, Beijing, Peoples R China
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2020年 / 393卷 / 12期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
lncRNA RHPN1-AS1; miR-485-5p; Proliferation; Metastasis; Hepatocellular carcinoma; METASTASIS; METABOLISM; PATHWAY; CELLS;
D O I：
10.1007/s00210-020-01889-z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
It is reported that long noncoding RNA RHPN1-AS1 (lncRNA RHPN1-AS1) functions as an oncogene among multiple types of cancers; however, the effect of lncRNA RHPN1-AS1 in hepatocellular carcinoma (HCC) is left to be investigated. The main purpose of this work was to study the effects of lncRNA RHPN1-AS1/miR-485-5p system on proliferation, migration, and invasion in HCC and future investigate the latent mechanisms. Our work found that lncRNA RHPN1-AS1 was observably up-regulated in HCC tissues and cell lines, especially HCCLM3 and SMMC-7721 cells. LncRNA RHPN1-AS1 knockdown decreased the capacity of proliferation, invasion, and migration in HCCLM3 and SMMC-7721 cells, which could be crippled by miR-485-5p inhibitor. Besides, the expression of basigin (BSG) was decreased after lncRNA RHPN1-AS1 silence, indicating the function of lncRNA RHPN1-AS1/miR-485-5p/BSG axis in HCC progression. Our study opens novel insights to help understand the mechanisms of lncRNA RHPN1-AS1/miR-485-5p/BSG axis in HCC progression, which may provide a new therapeutic target for HCC treatment.
引用
收藏
页码：2543 / 2551
页数：9
相关论文
共 26 条
[1]   Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis [J].
Bravi, Francesca ;
Bosetti, Cristina ;
Tavani, Alessandra ;
Gallus, Silvano ;
La Vecchia, Carlo .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (11) :1413-+
[2]   Cancer incidence and cancer control in Mongolia: Results from the National Cancer Registry 2008-12 [J].
Chimed, Tuvshinjargal ;
Sandagdorj, Tuvshingerel ;
Znaor, Ariana ;
Laversanne, Mathieu ;
Tseveen, Badamsuren ;
Genden, Purevsuren ;
Bray, Freddie .
INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (02) :302-309
[3]   The role of miR-485-5p/NUDT1 axis in gastric cancer [J].
Duan, Jingjing ;
Zhang, Haiyang ;
Li, Shuang ;
Wang, Xinyi ;
Yang, Haiou ;
Jiao, Shunchang ;
Ba, Yi .
CANCER CELL INTERNATIONAL, 2017, 17
[4]   CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway [J].
Huang, Qichao ;
Li, Jibin ;
Xing, Jinliang ;
Li, Weiwei ;
Li, Hongwei ;
Ke, Xia ;
Zhang, Jing ;
Ren, Tingting ;
Shang, Yukui ;
Yang, Hushan ;
Jiang, Jianli ;
Chen, Zhinan .
JOURNAL OF HEPATOLOGY, 2014, 61 (04) :859-866
[5]   The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion [J].
Jiang, Runqiu ;
Tang, Junwei ;
Chen, Yun ;
Deng, Lei ;
Ji, Jie ;
Xie, Yu ;
Wang, Ke ;
Jia, Wei ;
Chu, Wen-Ming ;
Sun, Beicheng .
NATURE COMMUNICATIONS, 2017, 8
[6]   Epidemiology and Management of Hepatocellular Carcinoma [J].
Kulik, Laura ;
El-Serag, Hashem B. .
GASTROENTEROLOGY, 2019, 156 (02) :477-+
[7]   CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Alct/mTOR/SRESP1c and P38/PPARα pathways [J].
Li, Jibin ;
Huang, Qichao ;
Long, Xiaoyu ;
Zhang, Jing ;
Huang, Xiaojun ;
Aa, Jiye ;
Yang, Hushan ;
Chen, Zhinan ;
Xing, Jinliang .
JOURNAL OF HEPATOLOGY, 2015, 63 (06) :1378-1389
[8]   RETRACTED: The lncRNA RHPN1-AS1 downregulation promotes gefitinib resistance by targeting miR-299-3p/TNFSF12 pathway in NSCLC (Retracted Article) [J].
Li, Xuehao ;
Zhang, Xin ;
Yang, Chunlu ;
Cui, Su ;
Shen, Qiming ;
Xu, Shun .
CELL CYCLE, 2018, 17 (14) :1772-1783
[9]   Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling [J].
Li, Yu ;
Zuo, Haibo ;
Wang, Hongjian ;
Hu, Anxiang .
BIOMEDICINE & PHARMACOTHERAPY, 2019, 116
[10]   Hepatocellular carcinoma [J].
Llovet, JM ;
Burroughs, A ;
Bruix, J .
LANCET, 2003, 362 (9399) :1907-1917
123