Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

被引:513
作者
Bachiller, Sara [1 ]
Jimenez-Ferrer, Itzia [2 ]
Paulus, Agnes [1 ]
Yang, Yiyi [1 ]
Swanberg, Maria [2 ]
Deierborg, Tomas [1 ]
Boza-Serrano, Antonio [1 ]
机构
[1] Lund Univ, Expt Neuroinflammat Lab, Lund, Sweden
[2] Lund Univ, Wallenberg Neurosci Ctr, Translat Neurogenet Unit, Lund, Sweden
来源
FRONTIERS IN CELLULAR NEUROSCIENCE | 2018年 / 12卷
基金
瑞典研究理事会;
关键词
microglia; Alzheimer's disease; Parkinson's disease; frontotemporal dementia; regional differences; inflammation; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; AMYLOID-BETA; MOUSE MODEL; FRONTOTEMPORAL DEMENTIA; RECEPTOR; GENE-EXPRESSION;
D O I
10.3389/fncel.2018.00488
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.
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页数:17
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共 220 条
[11]   Comparison of Inflammation in the Brain and Spinal Cord following Mechanical Injury [J].
Batchelor, Peter E. ;
Tan, Simon ;
Wills, Taryn E. ;
Porritt, Michelle J. ;
Howells, David W. .
JOURNAL OF NEUROTRAUMA, 2008, 25 (10) :1217-1225
[12]   Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease [J].
Bejanin, Alexandre ;
Schonhaut, Daniel R. ;
La Joie, Renaud ;
Kramer, Joel H. ;
Baker, Suzanne L. ;
Sosa, Natasha ;
Ayakta, Nagehan ;
Cantwell, Averill ;
Janabi, Mustafa ;
Lauriola, Mariella ;
O'Neil, James P. ;
Gorno-Tempini, Maria L. ;
Miller, Zachary A. ;
Rosen, Howard J. ;
Miller, Bruce L. ;
Jagust, William J. ;
Rabinovici, Gil D. .
BRAIN, 2017, 140 :3286-3300
[13]   Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation [J].
Bellucci, Arianna ;
Bugiani, Orso ;
Ghetti, Bernardino ;
Spillantini, Maria Grazia .
NEURODEGENERATIVE DISEASES, 2011, 8 (04) :221-229
[14]   TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy [J].
Bemiller, Shane M. ;
McCray, Tyler J. ;
Allan, Kevin ;
Formica, Shane V. ;
Xu, Guixiang ;
Wilson, Gina ;
Kokiko-Cochran, Olga N. ;
Crish, Samuel D. ;
Lasagna-Reeves, Cristian A. ;
Ransohoff, Richard M. ;
Landreth, Gary E. ;
Lamb, Bruce T. .
MOLECULAR NEURODEGENERATION, 2017, 12
[15]   The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes [J].
Berridge, CW ;
Waterhouse, BD .
BRAIN RESEARCH REVIEWS, 2003, 42 (01) :33-84
[16]   Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s [J].
Bhatia, Harsharan S. ;
Roelofs, Nora ;
Munoz, Eduardo ;
Fiebich, Bernd L. .
SCIENTIFIC REPORTS, 2017, 7
[17]   TDP-43 Variants of Frontotemporal Lobar Degeneration [J].
Bigio, Eileen H. .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2011, 45 (03) :390-401
[18]   MICROGLIAL-PRODUCED NITRIC-OXIDE AND REACTIVE NITROGEN-OXIDES MEDIATE NEURONAL CELL-DEATH [J].
BOJE, KM ;
ARORA, PK .
BRAIN RESEARCH, 1992, 587 (02) :250-256
[19]   Staging of brain pathology related to sporadic Parkinson's disease [J].
Braak, H ;
Del Tredici, K ;
Rüb, U ;
de Vos, RAI ;
Steur, ENHJ ;
Braak, E .
NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211
[20]   The role of the inferior frontal junction area in cognitive control [J].
Brass, M ;
Derrfuss, J ;
Forstmann, B ;
von Cramon, DY .
TRENDS IN COGNITIVE SCIENCES, 2005, 9 (07) :314-316