Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

被引：513

作者：

Bachiller, Sara ^{[1
]}

Jimenez-Ferrer, Itzia ^{[2
]}

Paulus, Agnes ^{[1
]}

Yang, Yiyi ^{[1
]}

Swanberg, Maria ^{[2
]}

Deierborg, Tomas ^{[1
]}

Boza-Serrano, Antonio ^{[1
]}

机构：

[1] Lund Univ, Expt Neuroinflammat Lab, Lund, Sweden

[2] Lund Univ, Wallenberg Neurosci Ctr, Translat Neurogenet Unit, Lund, Sweden

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2018年 / 12卷

基金：

瑞典研究理事会;

关键词：

microglia; Alzheimer's disease; Parkinson's disease; frontotemporal dementia; regional differences; inflammation; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; AMYLOID-BETA; MOUSE MODEL; FRONTOTEMPORAL DEMENTIA; RECEPTOR; GENE-EXPRESSION;

D O I：

10.3389/fncel.2018.00488

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.

引用

页数：17

共 220 条

[1] Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer's Disease [J].