Neuroprotection by hypoxic preconditioning:: HIF-1 and erythropoietin protect from retinal degeneration

被引：74

作者：

Grimm, C ^{[1
]}

Hermann, DM

Bogdanova, A

Hotop, S

Kilic, Ü

Wenzel, A

Kilic, E

Gassmann, M

机构：

[1] Univ Eye Hosp Zurich, Lab Retinal Cell Biol, CH-8091 Zurich, Switzerland

[2] Univ Zurich Hosp, Dept Neurol, Focal Brain Ischemia Lab, CH-8091 Zurich, Switzerland

[3] Univ Zurich, Vetsuisse Fac, Inst Vet Physiol, CH-8057 Zurich, Switzerland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 4-5期

关键词：

hypoxia-inducible factor-1; apoptosis; photoreceptor; ischemia; retinal ganglion cells;

D O I：

10.1016/j.semcdb.2005.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hypoxic exposure of cells or organisms induces expression of a number of hypoxia responsive genes through the activation of the hypoxia-inducible factor-1 (HIF-1). One of the most prominent HIF-1 targets is erythropoietin that has beneficial effects on ischemia-related injury in the brain. Exposure to low environmental oxygen concentrations can be used as a preconditioning paradigm to protect cells or tissues against a variety of harmful conditions. Here, we summarize recent work on neuroprotection of retinal photoreceptors and ganglion cells induced by hypoxic preconditioning or by systemically elevated levels of Epo in mouse plasma. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：531 / 538

页数：8

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