Invasive Non-Aspergillus Mold Infections in Transplant Recipients, United States, 2001-2006

被引：238

作者：

Park, Benjamin J. ^{[1
]}

Pappas, Peter G. ^{[2
]}

Wannemuehler, Kathleen A.

Alexander, Barbara D. ^{[3
]}

Anaissie, Elias J. ^{[4
]}

Andes, David R. ^{[5
]}

Baddley, John W. ^{[2
]}

Brown, Janice M. ^{[6
]}

Brumble, Lisa M. ^{[7
]}

Freifeld, Alison G. ^{[8
]}

Hadley, Susan ^{[9
]}

Herwaldt, Loreen ^{[10
]}

Ito, James I. ^{[11
]}

Kauffman, Carol A. ^{[12
,13
]}

Lyon, G. Marshall ^{[14
]}

Marr, Kieren A. ^{[15
,16
]}

Morrison, Vicki A. ^{[17
,18
]}

Papanicolaou, Genovefa ^{[19
]}

Patterson, Thomas F. ^{[20
,21
]}

Perl, Trish M. ^{[15
]}

Schuster, Mindy G. ^{[22
]}

Walker, Randall ^{[23
]}

Wingard, John R. ^{[24
]}

Walsh, Thomas J. ^{[25
]}

Kontoyiannis, Dimitrios P. ^{[26
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA

[2] Univ Alabama Birmingham, Med Ctr, Birmingham, AL 35294 USA

[3] Duke Univ, Med Ctr, Durham, NC USA

[4] Univ Arkansas Med Sci, Little Rock, AR 72205 USA

[5] Univ Wisconsin, Madison, WI USA

[6] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[7] Mayo Clin, Jacksonville, FL 32224 USA

[8] Univ Nebraska Med Ctr, Omaha, NE USA

[9] Tufts Med Ctr, Boston, MA USA

[10] Univ Iowa Hosp, Iowa City, IA USA

[11] City Hope Natl Med Ctr, Duarte, CA 91010 USA

[12] Univ Michigan, Ann Arbor, MI 48109 USA

[13] Vet Affairs Ann Arbor Healthcare Syst Med, Ann Arbor, MI USA

[14] Emory Univ, Sch Med, Atlanta, GA USA

[15] Johns Hopkins Med Inst, Baltimore, MD 21205 USA

[16] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[17] Univ Minnesota, Minneapolis, MN USA

[18] Vet Affairs Med Ctr, Minneapolis, MN USA

[19] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[20] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[21] S Texas Vet Healthcare Syst, San Antonio, TX USA

[22] Hosp Univ Penn, Philadelphia, PA 19104 USA

[23] Mayo Clin, Rochester, MN USA

[24] Univ Florida, Gainesville, FL USA

[25] NIH, Bethesda, MD 20892 USA

[26] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 10期

关键词：

HEMATOPOIETIC STEM-CELL; CARE CANCER CENTER; FUNGAL-INFECTIONS; BREAKTHROUGH ZYGOMYCOSIS; SCEDOSPORIUM-PROLIFICANS; ANTIFUNGAL THERAPY; VORICONAZOLE; EPIDEMIOLOGY; SURVEILLANCE; DNA;

D O I：

10.3201/eid1710.110087

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HOT recipients increased substantially during the surveillance period.

引用

页码：1855 / 1864

页数：10

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