Cardiovascular Pharmacogenomics

被引：60
作者：
Roden, Dan M. [1 ,2 ]
Johnson, Julie A. [3 ,4 ]
Kimmel, Stephen E. [5 ]
Krauss, Ronald M. [6 ]
Medina, Marisa Wong [6 ]
Shuldiner, Alan [7 ]
Wilke, Russell A. [2 ]
机构：
[1] Vanderbilt Univ, Sch Med, Oates Inst Expt Therapeut, Dept Med, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA
[3] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA
[4] Univ Florida, Ctr Pharmacogen, Coll Pharm, Gainesville, FL USA
[5] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
[6] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
[7] Univ Maryland, Sch Med, Baltimore, MD 21201 USA
来源：
CIRCULATION RESEARCH | 2011年 / 109卷 / 07期
基金：
美国国家卫生研究院;
关键词：
drug therapy; genetics; pharmacogenetics; pharmacogenomics; LONG-QT SYNDROME; LIPID-LOWERING RESPONSE; CLOPIDOGREL-TREATED PATIENTS; MODULATES CARDIAC REPOLARIZATION; 2C19-ASTERISK-17 ALLELIC VARIANT; LIPOPROTEIN CHOLESTEROL RESPONSE; ELECTRONIC MEDICAL-RECORDS; WARFARIN-DOSING-ALGORITHMS; ALPHA-ADDUCIN POLYMORPHISM; CORONARY STENT PLACEMENT;
D O I：
10.1161/CIRCRESAHA.110.230995
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented. (Circ Res. 2011; 109: 807-820.)
引用
收藏
页码：807 / 820
页数：14
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