Cardiovascular Pharmacogenomics

被引：60
作者：
Roden, Dan M. [1 ,2 ]
Johnson, Julie A. [3 ,4 ]
Kimmel, Stephen E. [5 ]
Krauss, Ronald M. [6 ]
Medina, Marisa Wong [6 ]
Shuldiner, Alan [7 ]
Wilke, Russell A. [2 ]
机构：
[1] Vanderbilt Univ, Sch Med, Oates Inst Expt Therapeut, Dept Med, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA
[3] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA
[4] Univ Florida, Ctr Pharmacogen, Coll Pharm, Gainesville, FL USA
[5] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
[6] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
[7] Univ Maryland, Sch Med, Baltimore, MD 21201 USA
来源：
CIRCULATION RESEARCH | 2011年 / 109卷 / 07期
基金：
美国国家卫生研究院;
关键词：
drug therapy; genetics; pharmacogenetics; pharmacogenomics; LONG-QT SYNDROME; LIPID-LOWERING RESPONSE; CLOPIDOGREL-TREATED PATIENTS; MODULATES CARDIAC REPOLARIZATION; 2C19-ASTERISK-17 ALLELIC VARIANT; LIPOPROTEIN CHOLESTEROL RESPONSE; ELECTRONIC MEDICAL-RECORDS; WARFARIN-DOSING-ALGORITHMS; ALPHA-ADDUCIN POLYMORPHISM; CORONARY STENT PLACEMENT;
D O I：
10.1161/CIRCRESAHA.110.230995
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented. (Circ Res. 2011; 109: 807-820.)
引用
收藏
页码：807 / 820
页数：14
相关论文
共 141 条
  • [1] Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    Aithal, GP
    Day, CP
    Kesteven, PJL
    Daly, AK
    [J]. LANCET, 1999, 353 (9154) : 717 - 719
  • [2] Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    Anderson, Jeffrey L.
    Horne, Benjamin D.
    Stevens, Scott M.
    Grove, Amanda S.
    Barton, Stephanie
    Nicholas, Zachery P.
    Kahn, Samera F. S.
    May, Heidi T.
    Samuelson, Kent M.
    Muhlestein, Joseph B.
    Carlquist, John F.
    [J]. CIRCULATION, 2007, 116 (22) : 2563 - 2570
  • [3] Variability in individual responsiveness to clopidogrel - Clinical implications, management, and future perspectives
    Angiolillo, Dominick J.
    Fernandez-Ortiz, Antonio
    Bernardo, Esther
    Alfonso, Fernando
    Macaya, Carlos
    Bass, Theodore A.
    Costa, Marco A.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (14) : 1505 - 1516
  • [4] A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
    Arking, Dan E.
    Pfeufer, Arne
    Post, Wendy
    Kao, W. H. Linda
    Newton-Cheh, Christopher
    Ikeda, Morna
    West, Kristen
    Kashuk, Carl
    Akyol, Mahmut
    Perz, Siegfried
    Jalilzadeh, Shapour
    Illig, Thomas
    Gieger, Christian
    Guo, Chao-Yu
    Larson, Martin G.
    Wichmann, H. Erich
    Marban, Eduardo
    O'Donnell, Christopher J.
    Hirschhorn, Joel N.
    Kaeaeb, Stefan
    Spooner, Peter M.
    Meitinger, Thomas
    Chakravarti, Aravinda
    [J]. NATURE GENETICS, 2006, 38 (06) : 644 - 651
  • [5] Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
    Assimes, Themistocles L.
    Holm, Hilma
    Kathiresan, Sekar
    Reilly, Muredach P.
    Thorleifsson, Gudmar
    Voight, Benjamin F.
    Erdmann, Jeanette
    Willenborg, Christina
    Vaidya, Dhananjay
    Xie, Changchun
    Patterson, Chris C.
    Morgan, Thomas M.
    Burnett, Mary Susan
    Li, Mingyao
    Hlatky, Mark A.
    Knowles, Joshua W.
    Thompson, John R.
    Absher, Devin
    Iribarren, Carlos
    Go, Alan
    Fortmann, Stephen P.
    Sidney, Stephen
    Risch, Neil
    Tang, Hua
    Myers, Richard M.
    Berger, Klaus
    Stoll, Monika
    Shah, Svati H.
    Thorgeirsson, Gudmundur
    Andersen, Karl
    Havulinna, Aki S.
    Herrera, J. Enrique
    Faraday, Nauder
    Kim, Yoonhee
    Kral, Brian G.
    Mathias, Rasika A.
    Ruczinski, Ingo
    Suktitipat, Bhoom
    Wilson, Alexander F.
    Yanek, Lisa R.
    Becker, Lewis C.
    Linsel-Nitschke, Patrick
    Lieb, Wolfgang
    Koenig, Inke R.
    Hengstenberg, Christian
    Fischer, Marcus
    Stark, Klaus
    Reinhard, Wibke
    Winogradow, Janina
    Grassl, Martina
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (19) : 1552 - 1563
  • [6] Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations
    Barber, Mathew J.
    Mangravite, Lara M.
    Hyde, Craig L.
    Chasman, Daniel I.
    Smith, Joshua D.
    McCarty, Catherine A.
    Li, Xiaohui
    Wilke, Russell A.
    Rieder, Mark J.
    Williams, Paul T.
    Ridker, Paul M.
    Chatterjee, Aurobindo
    Rotter, Jerome I.
    Nickerson, Deborah A.
    Stephens, Matthew
    Krauss, Ronald M.
    [J]. PLOS ONE, 2010, 5 (03):
  • [7] A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers
    Becker, Matthijs L.
    Visser, Loes E.
    Newton-Cheh, Christopher
    Hofman, Albert
    Uitterlinden, Andre G.
    Witteman, Jacqueline C. M.
    Stricker, Bruno H. Ch.
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 67 (01) : 61 - 67
  • [8] KCNMB1 genotype influences response to verapamil SIR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)
    Beitelshees, Amber L.
    Gong, Yan
    Wang, Danxin
    Schork, Nicholas J.
    Cooper-DeHoff, Rhonda M.
    Langaee, Taimour Y.
    Shriver, Mark D.
    Sadee, Wolfaana
    Knot, Harm J.
    Pepine, Carl J.
    Johnson, Julie A.
    [J]. PHARMACOGENETICS AND GENOMICS, 2007, 17 (09) : 719 - 729
  • [9] CACNA1C Gene Polymorphisms, Cardiovascular Disease Outcomes, and Treatment Response
    Beitelshees, Amber L.
    Navare, Hrishikesh
    Wang, Danxin
    Gong, Yan
    Wessel, Jennifer
    Moss, James I.
    Langaee, Taimour Y.
    Cooper-DeHoff, Rhonda M.
    Sadee, Wolfgang
    Pepine, Carl J.
    Schork, Nicolas J.
    Johnson, Julie A.
    [J]. CIRCULATION-CARDIOVASCULAR GENETICS, 2009, 2 (04) : 362 - U136
  • [10] Paraoxonase-1 is a major determinant of clopidogrel efficacy
    Bouman, Heleen J.
    Schoemig, Edgar
    van Werkum, Jochem W.
    Velder, Janna
    Hackeng, Christian M.
    Hirschhaeuser, Christoph
    Waldmann, Christopher
    Schmalz, Hans-Guenther
    ten Berg, Jurrien M.
    Taubert, Dirk
    [J]. NATURE MEDICINE, 2011, 17 (01) : 110 - U287
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