A randomized, controlled pilot trial of hormone therapy for menopausal insomnia

被引：18

作者：

Silva, Betania Huber ^{[1
]}

Martinez, Denis ^{[1
]}

Osorio Wender, Maria Celeste ^{[1
,2
,3
]}

机构：

[1] Univ Fed Rio Grande do Sul, Postgrad Program Med Sci, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Obstet & Gynecol, Porto Alegre, RS, Brazil

[3] Hosp Clin Porto Alegre, Menopause Clin, Porto Alegre, RS, Brazil

来源：

ARCHIVES OF WOMENS MENTAL HEALTH | 2011年 / 14卷 / 06期

关键词：

Sleep; Menopause; Hormone therapy; Polysomnography; Insomnia; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; SLEEP DISTURBANCE; HOT FLASHES; QUALITY;

D O I：

10.1007/s00737-011-0242-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Insomnia is a frequent climacteric symptom. This pilot, double-blind, randomized placebo-controlled trial compared estradiol associated with trimegestone or placebo in 12 women with perimenopausal insomnia. The Pittsburgh Sleep Quality Index (PSQI) was administered, and polysomnography was performed at baseline and after 28 days. Sleep efficiency and median score of the PSQI improved significantly in the hormone therapy group (HT) (p = 0.041 and p = 0.027, respectively) and not in placebo group. Perimenopausal insomnia improved after short-term HT.

引用

页码：505 / 508

页数：4

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