Influence of Addition of Antibiotics on Chemical and Surface Properties of Sol-Gel Coatings

被引:3
作者
Toirac, Beatriz [1 ]
Garcia-Casas, Amaya [1 ,2 ]
Monclus, Miguel A. [3 ]
Aguilera-Correa, John J. [4 ,5 ]
Esteban, Jaime [4 ,5 ]
Jimenez-Morales, Antonia [1 ,5 ,6 ]
机构
[1] Carlos III Univ Madrid, Mat Sci & Engn & Chem Engn Dept, Madrid 28911, Spain
[2] Basque Res & Technol Alliance BRTA, CIDETEC, Donostia San Sebastian 20014, Spain
[3] Madrid Inst Adv Studies IMDEA Mat, Micro & Nanomech Dept, Madrid 28906, Spain
[4] UAM, Clin Microbiol Dept, IIS Fdn Jimenez Diaz, Madrid 28040, Spain
[5] Inst Carlos III, ISCIII CIBER Enfermedades Infecciosas, CIBERINFEC, Madrid 28029, Spain
[6] Carlos III Univ Madrid, Alvaro Alonso Barba Technol Inst Chem & Mat, Madrid 28911, Spain
关键词
antibiotics-loaded sol-gel coatings; AFM; SEM; solid-state Si-29-NMR spectroscopy; Fourier-transform infrared spectroscopy; IN-VITRO BIOCOMPATIBILITY; CORROSION PROTECTION; INFECTION; FILMS; DEGRADATION; COMBINATION;
D O I
10.3390/ma15144752
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Infection is one of the most common causes that leads to joint prosthesis failure. In the present work, biodegradable sol-gel coatings were investigated as a promising controlled release of antibiotics for the local prevention of infection in joint prostheses. Accordingly, a sol-gel formulation was designed to be tested as a carrier for 8 different individually loaded antimicrobials. Sols were prepared from a mixture of MAPTMS and TMOS silanes, tris(tri-methylsilyl)phosphite, and the corresponding antimicrobial. In order to study the cross-linking and surface of the coatings, a battery of examinations (Fourier-transform infrared spectroscopy, solid-state Si-29-NMR spectroscopy, thermogravimetric analysis, SEM, EDS, AFM, and water contact angle, thickness, and roughness measurements) were conducted on the formulations loaded with Cefoxitin and Linezolid. A formulation loaded with both antibiotics was also explored. Results showed that the coatings had a microscale roughness attributed to the accumulation of antibiotics and organophosphites in the surface protrusions and that the existence of chemical bonds between antibiotics and the siloxane network was not evidenced.
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页数:20
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