Metal nanoparticles as labels for heterogeneous, chip-based DNA detection

被引：258
作者：
Fritzsche, W [1 ]
Taton, TA
机构：
[1] Inst Phys High Technol, Biotech Microsyst Dept, Jena, Germany
[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
NANOTECHNOLOGY | 2003年 / 14卷 / 12期
关键词：
D O I：
10.1088/0957-4484/14/12/R01
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The last decade has witnessed the development of a variety of metal nanoparticle-based techniques for DNA detection. High sensitivity and specificity, miniaturization, and cost-efficient detection are problems addressed by the use of nanoparticle labels in heterogeneous DNA detection schemes. The small label size, established bioconjugation chemistry, and the unusual optical and electrical properties of metal nanoparticles make them unique tools for DNA detection. This paper reviews the different physical characteristics of metal nanoparticles and their implementation in assays. It covers various optical as well as gravimetric, electrochemical and electrical methods for analysing nanoparticle-labelled analytes, and particularly DNA, at sensing surfaces.
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收藏
页码：R63 / R73
页数：11
相关论文
共 95 条
[1]   Compact disc with both numeric and genomic information as DNA microarray platform [J].
Alexandre, I ;
Houbion, Y ;
Collet, J ;
Hamels, S ;
Demarteau, J ;
Gala, JL ;
Remacle, J .
BIOTECHNIQUES, 2002, 33 (02) :435-+
[2]   Colorimetric silver detection of DNA microarrays [J].
Alexandre, I ;
Hamels, S ;
Dufour, S ;
Collet, J ;
Zammatteo, N ;
De Longueville, F ;
Gala, JL ;
Remacle, J .
ANALYTICAL BIOCHEMISTRY, 2001, 295 (01) :1-8
[3]   Organization of 'nanocrystal molecules' using DNA [J].
Alivisatos, AP ;
Johnsson, KP ;
Peng, XG ;
Wilson, TE ;
Loweth, CJ ;
Bruchez, MP ;
Schultz, PG .
NATURE, 1996, 382 (6592) :609-611
[4]   Gold nanoparticle-based quantitative electrochemical detection of amplified human cytomegalovirus DNA using disposable microband electrodes [J].
Authier, L ;
Grossiord, C ;
Brossier, P ;
Limoges, B .
ANALYTICAL CHEMISTRY, 2001, 73 (18) :4450-4456
[5]  
BAMDAD C, 1997, CURR PROTOCOL MOL BI, V20
[6]   High-sensitivity detection of DNA hybridization on microarrays using resonance light scattering [J].
Bao, P ;
Frutos, AG ;
Greef, C ;
Lahiri, J ;
Muller, U ;
Peterson, TC ;
Warden, L ;
Xie, XY .
ANALYTICAL CHEMISTRY, 2002, 74 (08) :1792-1797
[7]  
Bauer G, 1999, MIKROCHIM ACTA, V131, P107, DOI 10.1007/s006040050015
[8]   Strategies in the preparation of DNA oligonucleotide arrays for diagnostic applications [J].
Beaucage, SL .
CURRENT MEDICINAL CHEMISTRY, 2001, 8 (10) :1213-1244
[9]   THE FUNCTIONALIZATION OF OLIGONUCLEOTIDES VIA PHOSPHORAMIDITE DERIVATIVES [J].
BEAUCAGE, SL ;
IYER, RP .
TETRAHEDRON, 1993, 49 (10) :1925-1963
[10]  
Burstein E., 1982, SURFACE ENHANCED RAM, P67
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