TP53 rs1042522 and rs8064946 variants in myocardial infarction

被引：1
|
作者：
Hakobjanyan, A. [1 ,3 ]
Stahelova, A. [1 ,2 ,4 ,5 ]
Mrazek, F. [1 ,4 ,5 ]
Petrkova, J. [1 ,3 ,5 ,6 ]
Navratilova, Z. [1 ,3 ]
Petrek, M. [1 ,3 ,7 ]
机构：
[1] NAS RA, Inst Mol Biol, Yerevan, Armenia
[2] NAS RA, GS Davtyan Inst Hydropon Problems, Yerevan, Armenia
[3] Palacky Univ, Dept Pathol Physiol, Fac Med & Dent, Hnevotinska 3, CZ-75150 Olomouc, Czech Republic
[4] Palacky Univ, Dept Immunol, Fac Med & Dent, Olomouc, Czech Republic
[5] Univ Hosp Olomouc, Olomouc, Czech Republic
[6] Palacky Univ, Dept Internal Med Cardiol 1, Fac Med & Dent, Olomouc, Czech Republic
[7] Palacky Univ, Inst Mol & Translat Med, Olomouc, Czech Republic
来源：
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2018年 / 119卷 / 12期
关键词：
myocardial infarction; tumor suppressor protein p53; genes; polymorphism; single nucleotide; polymerase chain reaction; CORONARY-ARTERY-DISEASE; GENE POLYMORPHISM; COLORECTAL-CANCER; RISK; ASSOCIATION; DNA;
D O I：
10.4149/BLL_2018_136
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
OBJECTIVE: This study investigated the hypothesis that the single nucleotide polymorphisms (SNPs) of TP53 gene are related to a risk of myocardial infarction. METHODS: The coding SNP at codon 72 (rs1042522) and non-coding rs8064946 SNP were genotyped by polymerase chain reaction with sequence specific primers in 205 Czech patients with myocardial infarction and 148 Czech control subjects. RESULTS: The distribution of both SNPs was in agreement with the Hardy-Weinberg equilibrium and was similar to other European populations. Our power analysis showed 96 % of probability to detect an odd ratio equal to 2. Neither rs1042522 nor rs8064946 were associated with the risk of myocardial infarction. The haplotypes combined of rs1042522 and rs8064946 were not associated with myocardial infarction in the present study. CONCLUSION: The TP53 SNPs are not strongly associated with genetic predisposition to myocardial infarction.
引用
收藏
页码：747 / 751
页数：5
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