Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

被引：170

作者：

Ariazi, Jennifer ^{[1
]}

Benowitz, Andrew ^{[1
]}

De Biasi, Vern ^{[1
]}

Den Boer, Monique L. ^{[2
]}

Cherqui, Stephanie ^{[3
]}

Cui, Haifeng ^{[1
]}

Douillet, Nathalie ^{[4
]}

Eugenin, Eliseo A. ^{[5
,6
]}

Favre, David ^{[7
]}

Goodman, Spencer ^{[3
]}

Gousset, Karine ^{[8
]}

Hanein, Dorit ^{[9
]}

Israel, David I. ^{[10
]}

Kimura, Shunsuke ^{[11
]}

Kirkpatrick, Robert B. ^{[1
]}

Kuhn, Nastaran ^{[12
]}

Jeong, Claire ^{[13
]}

Lou, Emil ^{[14
]}

Mailliard, Robbie ^{[15
]}

Maio, Stephen ^{[13
]}

Okafo, George ^{[4
]}

Osswald, Matthias ^{[16
,17
,18
]}

Pasquier, Jennifer ^{[19
]}

Polak, Roel ^{[2
]}

Pradel, Gabriele ^{[20
]}

de Rooij, Bob

Schaeffer, Peter ^{[1
]}

Skeberdis, Vytenis A. ^{[21
]}

Smith, Ian F. ^{[22
]}

Tanveer, Ahmad ^{[23
]}

Volkmann, Niels ^{[9
]}

Wu, Zhenhua ^{[1
]}

Zurzolo, Chiara ^{[24
]}

机构：

[1] GlaxoSmithKline, Collegeville, PA USA

[2] Erasmus MC Sophia Childrens Hosp, Dept Pediat Oncol, Rotterdam, Netherlands

[3] Univ Calif San Diego, Dept Pediat, Div Genet, La Jolla, CA 92093 USA

[4] GlaxoSmithKline, Stevenage, Herts, England

[5] PHRI, Newark, NJ 07103 USA

[6] Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ USA

[7] GlaxoSmithKline, Res Triangle Pk, NC USA

[8] Calif State Univ Fresno, Coll Sci & Math, Dept Biol, Fresno, CA 93740 USA

[9] Sanford Burnham Prebys Med Discovery, Bioinformat & Syst Biol Program, La Jolla, CA USA

[10] GlaxoSmithKline, Waltham, MA USA

[11] Hokkaido Univ, Grad Sch Med, Lab Histol & Cytol, Sapporo, Hokkaido, Japan

[12] NCI, Div Canc Biol, Phys Sci Oncol Network, Canc Tissue Engn Collaborat Res Program,Struct Bi, Bethesda, MD 20892 USA

[13] GlaxoSmithKline, King Of Prussia, PA USA

[14] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA

[15] Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA USA

[16] Univ Hosp Heidelberg, Neurol Clin, Heidelberg, Germany

[17] Univ Hosp Heidelberg, Natl Ctr Tumor Dis, Heidelberg, Germany

[18] German Canc Res Ctr, German Canc Consortium DKTK, Clin Cooperat Unit Neurooncol, Heidelberg, Germany

[19] Qatar Fdn, Weill Cornell Med Coll Qatar, Dept Med Genet, Ar Rayyan, Qatar

[20] Rhein Westfal TH Aachen, Div Cellular & Appl Infect Biol, Aachen, Germany

[21] Lithuanian Univ Hlth Sci, Inst Cardiol, Kaunas, Lithuania

[22] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA

[23] NIH, Sect Intracellular Trafficking & Neurovirol, Bethesda, MD USA

[24] Pasteur Inst, Dept Cell Biol & Infect, Unit Membrane Trafficking & Pathogenesis, Paris, France

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2017年 / 10卷

基金：

美国国家卫生研究院;

关键词：

Alzheimer; inflammation; cancer; gap junctions; reactivation; MESENCHYMAL STEM-CELLS; MEMBRANE NANOTUBES; CROSS-PRESENTATION; MITOCHONDRIAL TRANSFER; CUTTING EDGE; CA2+ SIGNALS; IN-VITRO; T-CELLS; CYTONEMES; INDUCE;

D O I：

10.3389/fnmol.2017.00333

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.

引用

页数：12

共 103 条

[1]

Abounit Saida, 2015, Curr Protoc Cell Biol, V67, DOI 10.1002/0471143030.cb1210s67

[2] Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases [J].