A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones

被引：50

作者：

Cho, SD

Park, YD

Kim, JJ

Lee, SG

Ma, C

Song, SY

Joo, WH

Falck, JR

Shiro, M

Shin, DS ^{[1
]}

Yoon, YJ

机构：

[1] Gyeongsang Natl Univ, Dept Chem, Chinju 660701, South Korea

[2] Gyeongsang Natl Univ, Res Inst Nat Sci, Chinju 660701, South Korea

[3] Changwon Natl Univ, Dept Chem, Chang Won 641773, South Korea

[4] Changwon Natl Univ, Res Inst Nat Sci, Chang Won 641773, South Korea

[5] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[6] Rigaku Corp, Akishima, Tokyo 1968666, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 20期

关键词：

D O I：

10.1021/jo034593i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrido[2,3-b][1,4]oxazin-2-ones are conveniently prepared in excellent yields by a one-pot annulation of N-substituted-2-chloroacetamides with 2-halo-3-hydroxypyr-idines with use of cesium carbonate in refluxing acetonitrile. The key transformation features a Smiles rearrangement of the initial O-alkylation product and subsequent cyclization.

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页码：7918 / 7920

页数：3

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