Phylogenetic Comparison and Splicing Analysis of the U1 snRNP-specific Protein U1C in Eukaryotes

被引：2

作者：

Zhang, Kai-Lu ^{[1
,2
,3
]}

Zhou, Jian-Li ^{[1
]}

Yang, Jing-Fang ^{[4
]}

Zhao, Yu-Zhen ^{[1
]}

Das, Debatosh ^{[6
,7
]}

Hao, Ge-Fei ^{[4
]}

Wu, Caie ^{[5
]}

Zhang, Jianhua ^{[6
,7
]}

Zhu, Fu-Yuan ^{[2
]}

Chen, Mo-Xian ^{[2
]}

Zhou, Shao-Ming ^{[1
]}

机构：

[1] Shenzhen Childrens Hosp, Div Gastroenterol, Shenzhen, Peoples R China

[2] Nanjing Forestry Univ, Coll Biol & Environm, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing, Peoples R China

[3] Shandong Agr Univ, Coll Life Sci, State Key Lab Crop Biol, Tai An, Shandong, Peoples R China

[4] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China

[5] Nanjing Forestry Univ, Coll Light Ind & Food Engn, Nanjing, Jiangsu, Peoples R China

[6] Hong Kong Baptist Univ, Dept Biol, Hong Kong, Peoples R China

[7] Chinese Univ Hong Kong, State Key Lab Agrobiotechnol, Hong Kong, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

alternative splicing; phylogenetics; gene expression; splice site; U1-snRNP; AUTOANTIBODIES; COMPLEX; RECOGNIZES; PART;

D O I：

10.3389/fmolb.2021.696319

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a pivotal regulator of 5' splice site recognition, U1 small nuclear ribonucleoprotein (U1 snRNP)-specific protein C (U1C) regulates pre-mRNA splicing by interacting with other components of the U1 snRNP complex. Previous studies have shown that U1 snRNP and its components are linked to a variety of diseases, including cancer. However, the phylogenetic relationships and expression profiles of U1C have not been studied systematically. To this end, we identified a total of 110 animal U1C genes and compared them to homologues from yeast and plants. Bioinformatics analysis shows that the structure and function of U1C proteins is relatively conserved and is found in multiple copies in a few members of the U1C gene family. Furthermore, the expression patterns reveal that U1Cs have potential roles in cancer progression and human development. In summary, our study presents a comprehensive overview of the animal U1C gene family, which can provide fundamental data and potential cues for further research in deciphering the molecular function of this splicing regulator.</p>

引用

页数：13

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