2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary

被引：37

作者：

Losa, F. ^{[1
]}

Iglesias, L. ^{[2
]}

Pane, M. ^{[3
]}

Sanz, J. ^{[4
]}

Nieto, B. ^{[5
]}

Fuste, V. ^{[6
]}

de la Cruz-Merino, L. ^{[7
]}

Concha, A. ^{[8
]}

Balana, C. ^{[9
]}

Matias-Guiu, X. ^{[10
,11
]}

机构：

[1] Hosp St Joan Despi, Med Oncol Dept, Inst Catala Oncol, ICO Hosp, Carrer Jacint Verdaguer 90, Barcelona 08970, Spain

[2] Hosp Univ Doce Octubre, Med Oncol Dept, Madrid, Spain

[3] Hosp Univ Bellvitge, Pathol Dept, Barcelona, Spain

[4] Hosp Clin San Carlos, Pathol Dept, Madrid, Spain

[5] Hosp Univ Leon, Med Oncol Dept, Leon, Spain

[6] Hosp Santa Creu & Sant Pau, Pathol Dept, Barcelona, Spain

[7] Hosp Univ Virgen Macarena, Med Oncol Dept, Seville, Spain

[8] Hosp Univ A Coruna, Pathol Dept, La Coruna, Spain

[9] Inst Catala Oncol, Med Oncol Dept, Barcelona, Spain

[10] Hosp Univ Arnau de Vilanova Lleida, Pathol Dept, Barcelona, Spain

[11] Hosp Univ Bellvitge, IRBLLEIDA, IDIBELL, CIBERONC, Barcelona, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2018年 / 20卷 / 11期

关键词：

Cancer of unknown primary; Diagnosis; Immunohistochemistry; Biopsy; Prognosis; Chemotherapy; Molecular pathology; Histopathology; PANCREATIC NEUROENDOCRINE TUMORS; PRIMARY SITE; PRIMARY CUP; PRIMARY ORIGIN; THERAPEUTIC MANAGEMENT; METASTATIC TUMORS; CARCINOMA; EXPRESSION; SURVIVAL; TISSUE;

D O I：

10.1007/s12094-018-1899-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer of unknown primary (CUP) is defined as a heterogeneous group of tumours that present with metastasis, and in which attempts to identify the original site have failed. They differ from other primary tumours in their biological features and how they spread, which means that they can be considered a separate entity. There are several hypotheses regarding their origin, but the most plausible explanation for their aggressiveness and chemoresistance seems to involve chromosomal instability. Depending on the type of study done, CUP can account for 2-9% of all cancer patients, mostly 60-75years old. This article reviews the main clinical, pathological, and molecular studies conducted to analyse and determine the origin of CUP. The main strategies for patient management and treatment, by both clinicians and pathologists, are also addressed.

引用

页码：1361 / 1372

页数：12

共 71 条

[61] Suitability of Thoracic Cytology for New Therapeutic Paradigms in Non-small Cell Lung Carcinoma High Accuracy of Tumor Subtyping and Feasibility of EGFR and KRAS Molecular Testing [J].

Rekhtman, Natasha ;

Brandt, Suzanne M. ;

Sigel, Carlie S. ;

Friedlander, Maria A. ;

Riely, Gregory J. ;

Travis, William D. ;

Zakowski, Maureen F. ;

Moreira, Andre L. .

JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (03) :451-458

[62] Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer [J].

Riihimaeki, Matias ;

Thomsen, Hauke ;

Hemminki, Akseli ;

Sundquist, Kristina ;

Hemminki, Kari .

BMC CANCER, 2013, 13

[63] Time trends in survival from cancer of unknown primary: Small steps forward [J].

Riihimaki, M. ;

Hemminki, A. ;

Sundquist, K. ;

Hemminki, K. .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (10) :2403-2410

[64] Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site New Routes to Targeted Therapies [J].

Ross, Jeffrey S. ;

Wang, Kai ;

Gay, Laurie ;

Otto, Geoff A. ;

White, Emily ;

Iwanik, Kiel ;

Palmer, Gary ;

Yelensky, Roman ;

Lipson, Doron M. ;

Chmielecki, Juliann ;

Erlich, Rachel L. ;

Rankin, Andrew N. ;

Ali, Siraj M. ;

Elvin, Julia A. ;

Morosini, Deborah ;

Miller, Vincent A. ;

Stephens, Philip J. .

JAMA ONCOLOGY, 2015, 1 (01) :40-49

[65] Neuroendocrine Carcinoma of Unknown Primary Site [J].

Spigel, David R. ;

Hainsworth, John D. ;

Greco, F. Anthony .

SEMINARS IN ONCOLOGY, 2009, 36 (01) :52-59

[66] Quantitative reverse transcriptase-polyme rase chain reaction assay to identify metastatic carcinoma tissue of origin [J].

Talantov, Dimitri ;

Baden, Jonathan ;

Jatkoe, Tim ;

Hahn, Kristina ;

Yu, Jack ;

Rajpurohit, Yashoda ;

Jiang, Yiqiu ;

Choi, Chang ;

Ross, Jeffrey S. ;

Atkins, David ;

Wang, Yixin ;

Mazumder, Abhijit .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2006, 8 (03) :320-329

[67] Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary [J].

Tothill, Richard W. ;

Li, Jason ;

Mileshkin, Linda ;

Doig, Ken ;

Siganakis, Terence ;

Cowin, Prue ;

Fellowes, Andrew ;

Semple, Timothy ;

Fox, Stephen ;

Byron, Keith ;

Kowalczyk, Adam ;

Thomas, David ;

Schofield, Penelope ;

Bowtell, David D. .

JOURNAL OF PATHOLOGY, 2013, 231 (04) :413-423

[68] Prospective Gene Signature Study Using microRNA to Identify the Tissue of Origin in Patients with Carcinoma of Unknown Primary [J].

Varadhachary, Gauri R. ;

Spector, Yael ;

Abbruzzese, James L. ;

Rosenwald, Shai ;

Wang, Huamin ;

Aharonov, Ranit ;

Carlson, Heather R. ;

Cohen, Dalia ;

Karanth, Siddharth ;

Macinskas, Joanna ;

Lenzi, Renato ;

Chajut, Ayelet ;

Edmonston, Tina B. ;

Raber, Martin N. .

CLINICAL CANCER RESEARCH, 2011, 17 (12) :4063-4070

[69] Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin [J].

Vikesa, Jonas ;

Moller, Anne Kirstine H. ;

Kaczkowski, Bogumil ;

Borup, Rehannah ;

Winther, Ole ;

Henao, Ricardo ;

Krogh, Anders ;

Perell, Katharina ;

Jensen, Flemming ;

Daugaard, Gedske ;

Nielsen, Finn C. .

BMC CANCER, 2015, 15

[70] Everolimus for Advanced Pancreatic Neuroendocrine Tumors. [J].

Yao, James C. ;

Shah, Manisha H. ;

Ito, Tetsuhide ;

Bohas, Catherine Lombard ;

Wolin, Edward M. ;

Van Cutsem, Eric ;

Hobday, Timothy J. ;

Okusaka, Takuji ;

Capdevila, Jaume ;

de Vries, Elisabeth G. E. ;

Tomassetti, Paola ;

Pavel, Marianne E. ;

Hoosen, Sakina ;

Haas, Tomas ;

Lincy, Jeremie ;

Lebwohl, David ;

Oberg, Kjell .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (06) :514-523

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