Modeling oscillatory control in NF-κB, p53 and Wnt signaling

被引：61

作者：

Mengel, Benedicte ^{[1
]}

Hunziker, Alexander ^{[1
]}

Pedersen, Lykke ^{[1
]}

Trusina, Ala ^{[1
]}

Jensen, Mogens H. ^{[1
]}

Krishna, Sandeep ^{[1
,2
]}

机构：

[1] Niels Bohr Inst, Ctr Models Life, DK-2100 Copenhagen, Denmark

[2] Natl Ctr Biol Sci TIFR, Bangalore, Karnataka, India

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

SEGMENTATION CLOCK; TEMPORAL CONTROL; GENE-EXPRESSION; SELF-ORGANIZATION; PROTEIN DYNAMICS; MINIMAL MODEL; TIME; NETWORK; DEGRADATION; SPECIFICITY;

D O I：

10.1016/j.gde.2010.08.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oscillations are commonly observed in cellular behavior and span a wide range of timescales, from seconds in calcium signaling to 24 hours in circadian rhythms. In between lie oscillations with time periods of 1-5 hours seen in NF-kappa B, p53 and Wnt signaling, which play key roles in the immune system, cell growth/death and embryo development, respectively. In the first part of this article, we provide a brief overview of simple deterministic models of oscillations. In particular, we explain the mechanism of saturated degradation that has been used to model oscillations in the NF-kappa B, p53 and Wnt systems. The second part deals with the potential physiological role of oscillations. We use the simple models described earlier to explore whether oscillatory signals can encode more information than steady-state signals. We then discuss a few simple genetic circuits that could decode information stored in the average, amplitude or frequency of oscillations. The presence of frequency-detector circuit downstream of NF-kappa B or p53 would be a strong clue that oscillations are important for the physiological response of these signaling systems.

引用

页码：656 / 664

页数：9