Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line

被引：126
作者：
Ou, Henry C.
Raible, David W.
Rubel, Edwin W.
机构：
[1] Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA
[2] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA
[3] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA
[4] Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA
来源：
HEARING RESEARCH | 2007年 / 233卷 / 1-2期
关键词：
hair cell; cisplatin; zebrafish; ototoxicity; cell death; lateral line;
D O I：
10.1016/j.heares.2007.07.003
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death occurred Much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was established that cisplatin causes hair cell loss in the lateral line in a dose-dependent fashion. The kinetics of hair cell loss during exposure to different concentrations of cisplatin was also assessed and it was found that the onset of hair cell loss correlated with the accumulated dose of cisplatin. These data demonstrate the feasibility and repeatability of cisplatin damage protocols in the zebrafish lateral line and set the stage for future evaluations of modulation of cisplatin-induced hair cell death. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：46 / 53
页数：8
相关论文
共 40 条
[1]   Recent strategies for the use of paclitaxel in the treatment of urological malignancies [J].
Bokemeyer, C ;
Hartmann, JT ;
Kuczyk, MA ;
Truss, MC ;
Kollmannsberger, C ;
Beyer, J ;
Jonas, U ;
Kanz, L .
WORLD JOURNAL OF UROLOGY, 1998, 16 (02) :155-162
[2]   D-Methionine protects against cisplatin damage to the stria vascularis [J].
Campbell, KCM ;
Meech, RP ;
Rybak, LP ;
Hughes, LF .
HEARING RESEARCH, 1999, 138 (1-2) :13-28
[3]   D-Methionine provides excellent protection from cisplatin ototoxicity in the rat [J].
Campbell, KCM ;
Rybak, LP ;
Meech, RP ;
Hughes, L .
HEARING RESEARCH, 1996, 102 (1-2) :90-98
[4]   Histological effects of co-administration of an ACTH(4-9) analogue, ORG 2766, on cisplatin ototoxicity in the albino guinea pig [J].
Cardinaal, RM ;
de Groot, JCMJ ;
Huizing, EH ;
Veldman, JE ;
Smoorenburg, GF .
HEARING RESEARCH, 2000, 144 (1-2) :157-167
[5]   Cisplatin-induced ototoxicity: Morphological evidence of spontaneous outer hair cell recovery in albino guinea pigs? [J].
Cardinaal, RM ;
de Groot, JCMJ ;
Huizing, EH ;
Veldman, JE ;
Smoorenburg, GF .
HEARING RESEARCH, 2000, 144 (1-2) :147-156
[6]   Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio) [J].
Harris, JA ;
Cheng, AG ;
Cunningham, LL ;
MacDonald, G ;
Raible, DW ;
Rubel, EW .
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2003, 4 (02) :219-234
[7]   CIS-PLATINUM OTOTOXICITY [J].
HELSON, L ;
OKONKWO, E ;
ANTON, L ;
CVITKOVIC, E .
CLINICAL TOXICOLOGY, 1978, 13 (04) :469-478
[8]   Reactive oxygen species in chick hair cells after gentamicin exposure in vitro [J].
Hirose, K ;
Hockenbery, DM ;
Rubel, EW .
HEARING RESEARCH, 1997, 104 (1-2) :1-14
[9]   Dynamic studies of ototoxicity in mature avian auditory epithelium [J].
Hirose, K ;
Westrum, LE ;
Stone, JS ;
Zirpel, L ;
Rubel, EW .
OTOTOXICITY: BASIC SCIENCE AND CLINICAL APPLICATIONS, 1999, 884 :389-409
[10]   Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin [J].
Holzer, Alison K. ;
Manorek, Gerald H. ;
Howell, Stephen B. .
MOLECULAR PHARMACOLOGY, 2006, 70 (04) :1390-1394
1234