Synthesis and anticonvulsant activity of a series of benzamides

被引：6

作者：

Musso, DL

Boswell, GE

Mehta, NB

Soroko, FE

Burchall, CJ

机构：

[1] BURROUGHS WELLCOME CO, DIV ORGAN CHEM, RES TRIANGLE PK, NC 27709 USA

[2] BURROUGHS WELLCOME CO, DIV PHARMACOL, RES TRIANGLE PK, NC 27709 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 31卷 / 04期

关键词：

N-(2-(dimethylamino)-1,1-dimethylethyl)benzamide; anticonvulsant activity;

D O I：

10.1016/0223-5234(96)80370-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzamides containing N,N,2-trimethyl-1,2-propane diamine as the amide moiety was synthesized. The compounds were evaluated in the maximal electroshock (MES) and pentylenetetrazol (metrazole, MET) screens for anticonvulsant activity. The 3,5-trifluoromethyl, 3,5-dichloro, and 3-bromo analogues proved to be either equipotent with or more potent than phenytoin.

引用

收藏

页码：331 / 334

页数：4

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