Synthesis and anticonvulsant activity of a series of benzamides

被引：6
作者：
Musso, DL
Boswell, GE
Mehta, NB
Soroko, FE
Burchall, CJ
机构：
[1] BURROUGHS WELLCOME CO, DIV ORGAN CHEM, RES TRIANGLE PK, NC 27709 USA
[2] BURROUGHS WELLCOME CO, DIV PHARMACOL, RES TRIANGLE PK, NC 27709 USA
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 31卷 / 04期
关键词：
N-(2-(dimethylamino)-1,1-dimethylethyl)benzamide; anticonvulsant activity;
D O I：
10.1016/0223-5234(96)80370-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of benzamides containing N,N,2-trimethyl-1,2-propane diamine as the amide moiety was synthesized. The compounds were evaluated in the maximal electroshock (MES) and pentylenetetrazol (metrazole, MET) screens for anticonvulsant activity. The 3,5-trifluoromethyl, 3,5-dichloro, and 3-bromo analogues proved to be either equipotent with or more potent than phenytoin.
引用
收藏
页码：331 / 334
页数：4
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