Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle

被引：6
|
作者：
Gonzalez-Prendes, R. [1 ]
Quintanilla, R. [2 ]
Amills, M. [1 ,3 ]
机构：
[1] CSIC IRTA UAB UB, Ctr Res Agr Genom, Dept Anim Genet, Campus Univ Autonoma Barcelona, Bellaterra 08193, Spain
[2] IRTA, Anim Breeding & Genet Program, Torre Marimon 08140, Caldes De Montb, Spain
[3] Univ Autonoma Barcelona, Fac Vet, Dept Ciencia Anim & Aliments, Bellaterra 08193, Spain
来源：
ANIMAL GENETICS | 2017年 / 48卷 / 05期
关键词：
association analysis; gluteus medius; muscle gene expression; quantitative trait loci; transcriptional regulation; CANDIDATE GENES; COENZYME-A; ASSOCIATION; CHOLESTEROL; POPULATION; NETWORKS; GENOMICS; TRAITS; SET;
D O I：
10.1111/age.12586
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
A comprehensive and systematic view of the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have investigated the genetic regulation of 63 porcine genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. With this aim, we have performed an expression QTL (eQTL) scan in 104 pigs with available genotypes for the Illumina Porcine SNP60 chip and microarray measurements of gene expression in the gluteus medius muscle. Analysis of the data with GEMMA software revealed 13 cis- and 18 trans-eQTL modulating the expression of 19 loci. Genes regulated by eQTL participated in a wide array of lipid metabolism pathways such as the beta-oxidation of fatty acids, lipid biosynthesis and lipolysis, fatty acid activation and desaturation, lipoprotein uptake, apolipoprotein assembly and cholesterol trafficking. These data provide a first picture of the genetic regulation of loci involved in porcine lipid metabolism.
引用
收藏
页码：606 / 610
页数：5
相关论文
共 50 条
  • [1] Skeletal muscle expression analysis of fat metabolism genes in pig
    Zambonelli, Paolo
    Comella, Marco
    Braglia, Silvia
    Buttazzoni, Luca
    Davoli, Roberta
    ITALIAN JOURNAL OF ANIMAL SCIENCE, 2009, 8 : 171 - 173
  • [2] Differential regulation of the expression of lipid metabolism-related genes with skeletal muscle type in growing chickens
    Saneyasu, Takaoki
    Kimura, Sayaka
    Kitashiro, Ayana
    Tsuchii, Nami
    Tsuchihashi, Tatsuya
    Inui, Mariko
    Honda, Kazuhisa
    Kamisoyama, Hiroshi
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2015, 189 : 1 - 5
  • [3] Regulation of exercise-induced lipid metabolism in skeletal muscle
    Jordy, Andreas Borsting
    Kiens, Bente
    EXPERIMENTAL PHYSIOLOGY, 2014, 99 (12) : 1586 - 1592
  • [4] Editorial: Regulation of lipid metabolism in adipose tissue and skeletal muscle
    Jia, Zhihao
    Shan, Tizhong
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [5] Palmitate regulation of glucose and lipid metabolism in human skeletal muscle
    Ciaraldi, TP
    Rehman, N
    Carter, L
    Mohideen, P
    Mudaliar, S
    DIABETES, 1999, 48 : A252 - A252
  • [6] Candidate Genes of Regulation of Skeletal Muscle Energy Metabolism in Athletes
    Balberova, Olga V.
    Bykov, Evgeny V.
    Medvedev, German V.
    Zhogina, Margarita A.
    Petrov, Kirill V.
    Petrova, Marina M.
    Al-Zamil, Mustafa
    Trefilova, Vera V.
    Goncharova, Polina S.
    Shnayder, Natalia A.
    GENES, 2021, 12 (11)
  • [7] Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor γ expression in human skeletal muscle
    Lapsys, NM
    Kriketos, AD
    Lim-Fraser, M
    Poynten, AM
    Lowy, A
    Furler, SM
    Chisholm, DJ
    Cooney, GJ
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (11): : 4293 - 4297
  • [8] Identification of genomic regions, genetic variants and gene networks regulating candidate genes for lipid metabolism in pig muscle
    Passols, M.
    Llobet-Cabau, F.
    Sebastia, C.
    Castello, A.
    Valdes-Hernandez, J.
    Criado-Mesas, L.
    Sanchez, A.
    Folch, J. M.
    ANIMAL, 2023, 17 (12)
  • [9] Effect of dietary fish oil on the expression of genes involved in lipid metabolism in liver and skeletal muscle of lactating sows
    Gessner, D. K.
    Groene, B.
    Rosenbaum, S.
    Most, E.
    Hillen, S.
    Becker, S.
    Erhardt, G.
    Reiner, G.
    Eder, K.
    JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2016, 100 (02) : 337 - 347
  • [10] Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues
    de Souza Cordeiro, Leticia Maria
    Mario, Erica Guilhen
    Lima Moreira, Rolina Campos
    Rodrigues, Angelica Heringer
    Wanner, Samuel Penna
    Soares, Danusa Dias
    Botion, Leida Maria
    Matos Ferreira, Adaliene Versiani
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (11) : 18883 - 18893
12345