The expansive role of oxylipins on platelet biology

被引:79
作者
Yeung, Jennifer [1 ]
Hawley, Megan [1 ]
Holinstat, Michael [1 ,2 ]
机构
[1] Univ Michigan, Dept Pharmacol, 1150 W Med Ctr Dr,Room 2220D, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 2017年 / 95卷 / 06期
基金
美国国家卫生研究院;
关键词
Lipoxygenase; Cyclooxygenase; Oxygenases; Eicosanoids; Prostaglandins; Thrombosis; POLYUNSATURATED FATTY-ACIDS; ARACHIDONIC-ACID; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; 20-HYDROXYEICOSATETRAENOIC ACID; EPOXYEICOSATRIENOIC ACIDS; PROSTANOID RECEPTORS; ENDOTHELIAL-CELLS; MOLECULAR-CLONING; LIPOXIN FORMATION;
D O I
10.1007/s00109-017-1542-4
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear. This review highlights the burgeoning classes of oxylipins that have been found to regulate platelet function; however, their mechanism of action still remains to be elucidated.
引用
收藏
页码:575 / 588
页数:14
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