Evaluation of photochemical tissue bonding for closure of skin incisions and excisions

被引：75

作者：

Kamegaya, Y ^{[1
]}

Farinelli, WA ^{[1
]}

Echague, AVV ^{[1
]}

Akita, H ^{[1
]}

Gallagher, J ^{[1
]}

Flotte, TJ ^{[1
]}

Anderson, RR ^{[1
]}

Redmond, RW ^{[1
]}

Kochevar, IE ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA 02114 USA

来源：

LASERS IN SURGERY AND MEDICINE | 2005年 / 37卷 / 04期

关键词：

tissue repair; lasers; wound healing; skin; incision; excision; wound closure;

D O I：

10.1002/lsm.20221

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background and Objectives: Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions. Study Design/Materials and Methods: Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology. Results: Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks. Conclusion: PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.

引用

页码：264 / 270

页数：7

共 33 条

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