Diagnostic Accuracy of [11C]PIB Positron Emission Tomography for Detection of Cardiac Amyloidosis

被引：59

作者：

Rosengren, Sara ^{[1
]}

Clemmensen, Tor Skibsted ^{[2
]}

Tolbod, Lars ^{[3
]}

Granstam, Sven-Olof ^{[4
]}

Eiskjaer, Hans ^{[2
]}

Wikstrom, Gerhard ^{[5
]}

Vedin, Ola ^{[5
]}

Kero, Tanja ^{[6
]}

Lubberink, Mark ^{[6
,7
]}

Harms, Hendrik J. ^{[3
]}

Flachskampf, Frank A. ^{[4
]}

Baron, Tomasz ^{[4
]}

Carlson, Kristina ^{[1
]}

Mikkelsen, Fabian ^{[2
]}

Antoni, Gunnar ^{[8
]}

Andersen, Niels Frost ^{[9
]}

Poulsen, Steen Hvitfeldt ^{[2
]}

Sorensen, Jens ^{[3
,6
]}

机构：

[1] Uppsala Univ, Department Med Sci, Hematol, Uppsala, Sweden

[2] Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark

[3] Aarhus Univ Hosp, Dept Nucl Med & PET, Aarhus, Denmark

[4] Uppsala Univ, Clin Physiol, Dept Med Sci, Uppsala, Sweden

[5] Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden

[6] Uppsala Univ, Dept Surg Sci, Radiol, Uppsala, Sweden

[7] Uppsala Univ, Dept Med Phys, Uppsala, Sweden

[8] Uppsala Univ, Dept Med Chem, Uppsala, Sweden

[9] Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark

来源：

JACC-CARDIOVASCULAR IMAGING | 2020年 / 13卷 / 06期

关键词：

diagnosis; heart; nuclear imaging; PET; Pittsburgh compound B; VISUALIZATION; C-11-PIB; AL; INVOLVEMENT; DEPOSITS; HEART;

D O I：

10.1016/j.jcmg.2020.02.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES This dual-site study evaluated the diagnostic accuracy of the method. BACKGROUND Pittsburgh compound ([C-11]PIB) positron emission tomography (PIB-PET) has shown promise as a specific and noninvasive method for the diagnosis of cardiac amyloidosis (CA). METHODS The study had 2 parts. In the initial study, 51 subjects were included, 36 patients with known CA and increased wall thickness (15 immunoglobulin light chain [AL] and 21 transthyretin [ATTR] amyloidosis) and 15 control patients (7 were nonamyloid hypertrophic and 8 healthy volunteers). Subjects underwent PIB-PET and echocardiography. Sensitivity and specificity of PIB-PET were established for 2 simple semiquantitative approaches, standardized uptake value ratio (SUVR) and retention index (RI). The second part of the study included (11) amyloidosis patients (5 AL and 6 hereditary ATTR) without increased wall thickness to which the optimal cutoff values of SUVR (>1.09) and RI (>0.037 min-1) were applied prospectively. RESULTS The diagnostic accuracy of visual inspection of [C-11]PIB uptake was 100% in discriminating CA patients with increased wall thickness from controls. Semiquantitative [C-11]PIB uptake discriminated CA from controls with a 94% (95% confidence interval [CI]: 80% to 99%) sensitivity for both SUVR and RI and specificity of 93% (95% CI: 66% to 100%) for SUVR and 100% (95% CI: 75% to 100%) for RI. [C-11]PIB uptake was significantly higher in AL-CA than in ATTR-CA patients (p < 0.001) and discriminated AL-CA from controls with 100% (95% CI: 88% to 100%) accuracy for both the semiquantitative measures. In the prospective group without increased wall thickness, RI was elevated compared to controls (p = 0.001) and 5 of (11) subjects were evaluated as [C-11]PIB PET positive. CONCLUSIONS In a dual-center setting, [C-11]PIB PET was highly accurate in detecting cardiac involvement in the main amyloid subtypes, with 100% accuracy in AL amyloidosis. A proportion of amyloidosis patients without known cardiac involvement were [C-11]PIB PET positive, indicating that the method may detect early stages of CA. (c) 2020 by the American College of Cardiology Foundation.

引用

页码：1337 / 1347

页数：11