Comparison of mouse strains for susceptibility to styrene-induced hepatotoxicity and pneumotoxicity

被引:35
作者
Carlson, GP
机构
[1] School of Health Sciences, Purdue University, West Lafayette, IN
来源
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1997年 / 51卷 / 02期
关键词
D O I
10.1080/00984109708984020
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Styrene is known to cause both hepatotoxicity and pneumotoxicity in mice. Strain differences have been reported by other investigators suggesting that Swiss mice are less susceptible than non-Swiss mice to styrene-induced liver damage. in this study, A/J and C57BL/6 mice were found to be similar to non-Swiss albino (NSA) mice in susceptibility whereas CD-1 (Swiss) mice were more resistant to hepatotoxicity as assessed by serum sorbitol dehydrogenase levels and pneumotoxicity as determined by gamma-glutamyltranspeptidase and lactate dehydrogenase measurements in bronchoalveolar lavage fluid. Styrene was hepatotoxic in CD-1 mice treated with pyridine to induce CYP2E1. CYP2E1 apoprotein levels and p-nitrophenol hydroxylase activities in control and pyridine-induced mice were similar in the two strains. Hepatic and pulmonary microsomal preparations from both strains metabolized styrene to styrene oxide at similar rates. CD-1 mice were as susceptible as the NSA mice to the effects of styrene oxide. The data suggest that there are no differences in the bioactivation of styrene to styrene oxide or innate susceptibility to the active metabolite that would account for the differences between the CD-1 and NSA mice.
引用
收藏
页码:177 / 187
页数:11
相关论文
共 26 条
  • [11] KIM SG, 1991, J PHARMACOL EXP THER, V259, P470
  • [12] LEIBMAN KC, 1968, PHARMACOLOGIST, V10, P203
  • [13] SUSCEPTIBILITY TO URETHAN-INDUCED PULMONARY ADENOMAS BETWEEN A/J AND C57BL/6J MICE - USE OF AXB AND BXA RECOMBINANT INBRED LINES INDICATING A 3-LOCUS GENETIC MODEL
    MALKINSON, AM
    NESBITT, MN
    SKAMENE, E
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1985, 75 (05) : 971 - 974
  • [14] STYRENE PRODUCTION, USE, AND HUMAN EXPOSURE
    MILLER, RR
    NEWHOOK, R
    POOLE, A
    [J]. CRITICAL REVIEWS IN TOXICOLOGY, 1994, 24 : S1 - S10
  • [15] STYRENE INHALATION TOXICITY STUDIES IN MICE .3. STRAIN DIFFERENCES IN SUSCEPTIBILITY
    MORGAN, DL
    MAHLER, JF
    DILL, JA
    PRICE, HC
    OCONNOR, RW
    ADKINS, B
    [J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1993, 21 (03): : 326 - 333
  • [16] STYRENE INHALATION TOXICITY STUDIES IN MICE .1. HEPATOTOXICITY IN B6C3F1 MICE
    MORGAN, DL
    MAHLER, JF
    OCONNOR, RW
    PRICE, HC
    ADKINS, B
    [J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1993, 20 (03): : 325 - 335
  • [17] COMPARISON OF STYRENE HEPATOTOXICITY IN B6C3F1 AND SWISS MICE
    MORGAN, DL
    MAHLER, JF
    MOORMAN, MP
    WILSON, RE
    PRICE, HC
    RICHARDS, JH
    OCONNOR, RW
    [J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1995, 27 (02): : 217 - 222
  • [18] NAKAJIMA T, 1994, BIOCHEM PHARMACOL, V48, P637
  • [19] STYRENE METABOLISM BY CDNA-EXPRESSED HUMAN HEPATIC AND PULMONARY CYTOCHROMES P450
    NAKAJIMA, T
    ELOVAARA, E
    GONZALEZ, FJ
    GELBOIN, HV
    RAUNIO, H
    PELKONEN, O
    VAINIO, H
    AOYAMA, T
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1994, 7 (06) : 891 - 896
  • [20] INDUCTION, ACTIVATION AND INHIBITION OF EPOXIDE HYDRASE - ANOMALOUS PREVENTION OF CHLOROBENZENE-INDUCED HEPATOTOXICITY BY AN INHIBITOR OF EPOXIDE HYDRASE
    OESCH, F
    JERINA, DM
    DALY, JW
    RICE, JM
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1973, 6 (03) : 189 - 202