Polymorphism identification in the goat KITLG gene and association analysis with litter size

被引：26

作者：

An, X. P. ^{[1
]}

Hou, J. X. ^{[1
]}

Li, G. ^{[1
]}

Song, Y. X. ^{[1
]}

Wang, J. G. ^{[1
]}

Chen, Q. J. ^{[1
]}

Cui, Y. H. ^{[1
]}

Wang, Y. F. ^{[1
]}

Cao, B. Y. ^{[1
]}

机构：

[1] NW A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

来源：

ANIMAL GENETICS | 2012年 / 43卷 / 01期

关键词：

goat; haplotype; linkage disequilibrium; polymorphisms; STEM-CELL FACTOR; PRIMORDIAL FOLLICLE DEVELOPMENT; C-KIT; MAMMALIAN OOGENESIS; OOCYTE GROWTH; LIGAND; EXPRESSION; FOLLICULOGENESIS; OVARIES; MOUSE;

D O I：

10.1111/j.1365-2052.2011.02219.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

This study reported the analysis of KIT ligand (KITLG) gene polymorphisms in 681 goats of three breeds: Xinong Saanen (SN), Guanzhong (GZ), and Boer (BG). In addition, the study identified three allelic variants: g.769T>C and g.817G>T in SN and GZ breeds, and g.9760G>C in the three goat breeds. The g.769T>C and g.817G>T loci were closely linked (r2 > 0.33). All the single nucleotide polymorphism loci were in HardyWeinberg disequilibrium (P < 0.05). Significant associations were found for litter size with all three loci. Therefore, these results suggest that the KITLG gene is a strong candidate gene affecting litter size in goats.

引用

页码：104 / 107

页数：4

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