Corneal endothelial cytotoxicity of the Calotropis procera (ushaar) plant

Purpose: To report 6 eyes of 5 patients with transient corneal edema after exposure to the milky latex of Calotropis procera (ushaar). Methods: Interventional case series. Results: intracorneal penetration of ushaar latex can lead to permanent endothelial cell loss with morphologic alteration. Corneal edema resolved completely in similar to 2 weeks in all cases, despite reduced endothelial cell count and abnormal morphology. Conclusions: Corneal endothelial toxicity of ushaar latex is caused by its ability to penetrate the corneal stroma and induce permanent loss of endothelial cells. Corneal edema resolves if sufficient endothelial cell viability is still present after resolution of ushaar keratitis.