Note: Integration of trapped ion mobility spectrometry with mass spectrometry

被引：196

作者：

Fernandez-Lima, F. A. ^{[1
]}

Kaplan, D. A. ^{[2
]}

Park, M. A. ^{[2
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

[2] Bruker Daltonics Inc, Billerica, MA 01821 USA

来源：

REVIEW OF SCIENTIFIC INSTRUMENTS | 2011年 / 82卷 / 12期

关键词：

ion mobility; ion sources; mass spectroscopy; trapped ions;

D O I：

10.1063/1.3665933

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIMS mobility resolution depends on the analysis scan speed and the bath gas velocity, with the unique advantage that the IMS separation can be easily tuned from high speed (similar to 25 ms) for rapid analysis to slower scans for higher mobility resolution (R > 80). (C) 2011 American Institute of Physics. [doi:10.1063/1.3665933]

引用

页数：3