A facile synthesis of N-substituted 2,5-dimethylpyrroles with saccharin as a green catalyst

被引：9
|
作者：
Bhandari, Namratha [1 ]
Gaonkar, Santosh L. [1 ]
机构：
[1] Manipal Univ, Manipal Inst Technol, Dept Chem, Manipal 576104, Karnataka, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 51卷 / 04期
关键词：
pyrrole; saccharin; cyclocondensation; Paal-Knorr reaction; ONE-POT SYNTHESIS; KNORR PYRROLES SYNTHESIS; SOLVENT-FREE CONDITIONS; BIOLOGICAL EVALUATION; SULFURIC-ACID; DERIVATIVES; CITALOPRAM; EFFICIENT; AGENTS; ANTIBACTERIAL;
D O I：
10.1007/s10593-015-1701-x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The paper describes a convenient method for the preparation of N-substituted 2,5-dimethylpyrroles using edible sweetener saccharin. Various heterocyclic and aromatic hydrazides have been converted to their corresponding Paal-Knorr pyrroles at room temperature in methanol with saccharin as a green catalyst. Saccharin can be recycled for the next two runs without apparent loss in its activity. Here we propose a method which is speedy, proficient, and ecologically safe.
引用
收藏
页码：320 / 323
页数：4
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