Mechanisms of tumor growth retardation by modulation of pH regulation in the tumor-microenvironment of a murine T cell lymphoma

被引：27

作者：

Vishvakarma, Naveen Kumar ^{[1
]}

Singh, Sukh Mahendra ^{[1
]}

机构：

[1] Banaras Hindu Univ, Sch Biotechnol, Varanasi 221005, Uttar Pradesh, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2011年 / 65卷 / 01期

关键词：

Pantoprazole; Apoptosis; Tumor retardation; PROTON-PUMP INHIBITORS; GASTRIC-ACID SUPPRESSION; HYPOXIA-INDUCIBLE FACTOR; NITRIC-OXIDE PRODUCTION; L-SELECTIN; GENDER DIMORPHISM; HOST-BEARING; CANCER; APOPTOSIS; EXPRESSION;

D O I：

10.1016/j.biopha.2010.06.012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mechanisms underlying tumor growth retarding effect of proton pump inhibitor pantoprazole (PPZ) on a murine T cell lymphoma, designated as Dalton's lymphoma (DL), were investigated. In vivo administration of PPZ to tumor-bearing mice resulted in retardation of tumor progression owing to an inhibition of tumor cell survival and augmented apoptosis. An alteration in the parameters of tumor microenvironment and modulation in the expression of cell growth regulatory molecules is indicated to be involved in PPZ-dependent tumor growth retardation. These findings will help in optimizing therapeutic strategies against cancer using PPZ. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：27 / 39

页数：13

共 55 条

[1] Defining microenvironments within mouse models that enhance tumor aggressiveness [J].

Basu, Devraj ;

Herlyn, Meenhard .

CANCER BIOLOGY & THERAPY, 2009, 8 (04) :380-381

[2] Role of selectins in the tnggenng, growth, and dissemination of T-lymphorna cells:: implication of L-selectin in the growth of thymic lymphorna [J].

Bélanger, SD ;

St-Pierre, Y .

BLOOD, 2005, 105 (12) :4800-4806

[3] One hundred years of cancer immunotherapy: A critical appraisal [J].

Ben-Efraim, S .

TUMOR BIOLOGY, 1999, 20 (01) :1-24

[4] Inhibition of macrophage nitric oxide production by gangliosides derived from a spontaneous T cell lymphoma: the involved mechanisms [J].

Bharti, AC ;

Singh, SM .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2003, 8 (01) :75-82

[5] Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness [J].

Brett, S .

CRITICAL CARE, 2005, 9 (01) :45-50

[6] Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment [J].

Cairns, R ;

Papandreou, I ;

Denko, N .

MOLECULAR CANCER RESEARCH, 2006, 4 (02) :61-70

[7] VARIATIONS IN TUMOR-CELL GROWTH-RATES AND METABOLISM WITH OXYGEN CONCENTRATION, GLUCOSE-CONCENTRATION, AND EXTRACELLULAR PH [J].

CASCIARI, JJ ;

SOTIRCHOS, SV ;

SUTHERLAND, RM .

JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 151 (02) :386-394

[8]

Chaudburi Rupak Kr., 2006, Indian Journal of Experimental Biology, V44, P254

[9] Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cells [J].

Chen, Min ;

Zou, Xiaoping ;

Luo, Hesheng ;

Cao, Jun ;

Zhang, Xiaoqi ;

Zhang, Bin ;

Liu, Wenjia .

CELL BIOLOGY INTERNATIONAL, 2009, 33 (09) :1008-1019

[10] Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH [J].

Chiche, Johanna ;

Ilc, Karine ;

Laferriere, Julie ;

Trottier, Eric ;

Dayan, Frederic ;

Mazure, Nathalie M. ;

Brahimi-Horn, M. Christiane ;

Pouyssegur, Jacques .

CANCER RESEARCH, 2009, 69 (01) :358-368

← 1 2 3 4 5 6 →