Synthesis and bioactivity of novel methyl 6-deoxy-6(N′-alkyl/aryl-N"-benzothiazol-2-yl)guanidino-α-D-glucopyranosides

被引：14

作者：

Liu, Yong-Hua ^{[1
]}

Cao, Ling-Hua ^{[1
]}

机构：

[1] Xinjiang Univ, Coll Chem & Chem Engn, Urumqi 830046, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 04期

基金：

中国国家自然科学基金;

关键词：

sugar isothiocyanate; sugar-thiourea; guanidinoglucoside; 2-aminobenzothiazole; anti-influenza activity;

D O I：

10.1016/j.carres.2007.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of new methyl 6-deoxy-6-[N'-alkyl/aryl-N"-(benzothiazol-2-yl)]guanidino-alpha-D-glucopyranosides were obtained from the reaction of an alkyl/aryl amine in the presence of HgCl2 and sugar-thiourea derivatives, followed by the removal of protecting groups. The sugar-thiourea derivatives were obtained from the treatment of 2-aminobenzothiazole derivatives with methyl 2,3,4-tri-O-acetyl-6-deoxy-6-isothiocyanato-alpha-D-glucopyranoside in dry pyridine. Some of the synthesized guanidines displayed anti-influenza activity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：615 / 625

页数：11

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