S100B Maternal Blood Levels in Gestational Diabetes Mellitus Are Birthweight, Gender and Delivery Mode Dependent

被引：4

作者：

Abella, Laura ^{[1
]}

D'Adamo, Ebe ^{[2
]}

Strozzi, Mariachiara ^{[3
]}

Sanchez-de-Toledo, Joan ^{[4
]}

Perez-Cruz, Miriam ^{[4
]}

Gomez, Olga ^{[4
]}

Abella, Ernesto ^{[5
]}

Cassinari, Maurizio ^{[3
]}

Guaschino, Roberto ^{[3
]}

Mazzucco, Laura ^{[3
]}

Maconi, Antonio ^{[3
]}

Testa, Stefania ^{[3
]}

Zanelli, Cristian ^{[3
]}

Perrotta, Marika ^{[2
]}

Roberta, Patacchiola ^{[6
]}

Renata, Neri Costanza ^{[6
]}

Gasparroni, Giorgia ^{[2
]}

Vitacolonna, Ester ^{[7
]}

Chiarelli, Francesco ^{[6
]}

Gazzolo, Diego ^{[2
]}

机构：

[1] Hosp Univ Dexeus, Barcelona 08028, Spain

[2] Univ G dAnnunzio, Neonatal Intens Care Unit, I-65100 Chieti, Italy

[3] ASO SS Antonio, Neonatal Intens Care Unit, I-16100 C Arrigo, Alessandria, Italy

[4] Univ Barcelona, Hosp St Joan de Deus, Fetal Med Res Ctr, Barcelona 08950, Spain

[5] Hosp Dr Max Peralta Jimenez, Cartago 30101, Costa Rica

[6] Univ G dAnnunzio, Dept Pediat, I-65100 Chieti, Italy

[7] Univ G dAnnunzio, Sch Med & Hlth Sci, Dept Med & Aging, I-65100 Chieti, Italy

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2022年 / 19卷 / 03期

关键词：

biomarker; brain development; fetus; newborn; pregnancy; S100B; gestational diabetes mellitus; PROTEIN CONCENTRATIONS; WHITE-MATTER; BRAIN-DAMAGE; EARLY IDENTIFICATION; HEALTHY PRETERM; AGE; TERM; INFANTS; FLUID; PREGNANCY;

D O I：

10.3390/ijerph19031028

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Gestational Diabetes Mellitus (GDM) is one of the main causes of perinatal mortality/morbidity. Today, a parameter offering useful information on fetal central nervous system (CNS) development/damage is eagerly awaited. We investigated the role of brain-protein S100B in the maternal blood of GDM pregnancies by means of a prospective case-control study in 646 pregnancies (GDM: n = 106; controls: n = 530). Maternal blood samples for S100B measurement were collected at four monitoring time-points from 24 weeks of gestation to term. Data was corrected for gender and delivery mode and correlated with gestational age and weight at birth. Results showed higher (p < 0.05) S100B from 24 to 32 weeks and at term in GDM fetuses than controls. Higher (p < 0.05) S100B was observed in GDM male new-borns than in females from 24 to 32 weeks and at term, in GDM cases delivering vaginally than by caesarean section. Finally, S100B positively correlated with gestational age and weight at birth (R = 0.27; R = 0.37, respectively; p < 0.01). The present findings show the usefulness of S100B in CNS to monitor high-risk pregnancies during perinatal standard-of-care procedures. The results suggest that further investigations into its potential role as an early marker of CNS growth/damage in GDM population are needed.

引用

页数：10

共 41 条

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