Lack of association between serotonin transporter promoter gene polymorphism and citalopram response in major depressive disorder

被引：0

作者：

Kang, Rhee-Hun ^{[1
,2
,3
]}

Choi, Myoung-Jin ^{[2
,3
]}

Chang, Hun Soo ^{[2
,3
]}

Hahn, Sang-Woo ^{[4
]}

Lee, Hwa-Young ^{[1
,2
,3
]}

Paik, Jong-Woo ^{[5
]}

Lim, Se-Won ^{[6
]}

Oh, Kang-Seob ^{[6
]}

Jung, Han-Yong ^{[4
]}

Lee, Min-Soo ^{[1
,2
,3
]}

机构：

[1] Korea Univ, Coll Med, Dept Psychiat, Seoul 136705, South Korea

[2] Korea Univ, Clin Res Ctr Depress, Seoul 136701, South Korea

[3] Korea Univ, Inst Human Behav & Gene, Seoul 136701, South Korea

[4] Soonchunhyang Univ, Coll Med, Dept Psychiat, Seoul 140743, South Korea

[5] Kyung Hee Univ, Coll Med, Dept Psychiat, Seoul 130702, South Korea

[6] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Coll Med, Dept Psychiat,Sch Med, Seoul 110746, South Korea

来源：

MOLECULAR & CELLULAR TOXICOLOGY | 2008年 / 4卷 / 01期

关键词：

MDD; 5-HTTLPR; polymorphism; citalopram;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 5-HTT gene is a candidate gene for influencing the clinical response to antidepressant treatment. The purpose of this gene study was to determine the relationship between serotonin transporter gene polymorphism at the SLC6A4 and the response to citalopram in a Korean population with major depressive disorder (MDD). Citalopram was administered for 8 weeks to the 80 patients who completed this study. The severity of depression was assessed with the 21-item Hamilton Depression Rating scale, and the 5-HTTLPR genotypes in the patients were determined using the polymerase chain reaction. Our result did not showed significant differences in, allele, and carrier distribution between the normal group and MDD patients. This study suggest that polymorphism of the 5HTT gene was not associated with citalopram response to MDD in the Korean population.

引用

页码：1 / 4

页数：4

共 19 条

[1] 5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study [J].

Arias, B ;

Catalán, R ;

Gastó, C ;

Gutiérrez, B ;

Fañanás, L .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2003, 23 (06) :563-567

[2] COMPARATIVE PHARMACOKINETICS OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS - A LOOK BEHIND THE MIRROR [J].

BAUMANN, P ;

ROCHAT, B .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1995, 10 :15-21

[3]

BUCHNER A, 1996, PRIORI POSTHOC COMPR

[4]

Greenberg BD, 1999, AM J MED GENET, V88, P83, DOI 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO

[5]

2-0

[6]

Heils A, 1996, J NEUROCHEM, V66, P2621

[7] Serotonin transporter gene polymorphism and antidepressant response [J].

Kim, DK ;

Lim, SW ;

Lee, S ;

Sohn, SE ;

Kim, S ;

Hahn, CG ;

Carroll, BJ .

NEUROREPORT, 2000, 11 (01) :215-219

[8] Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression [J].

Kim, Hyeran ;

Lim, Shinn-Won ;

Kim, Seonwoo ;

Kim, Jong-Won ;

Chang, Yun Hee ;

Carroll, Bernard J. ;

Kim, Doh Kwan .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (13) :1609-1618

[9]

KIM JW, 2003, KOREAN SOC BIOL PSYC

[10] Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region [J].

Lesch, KP ;

Bengel, D ;

Heils, A ;

Sabol, SZ ;

Greenberg, BD ;

Petri, S ;

Benjamin, J ;

Muller, CR ;

Hamer, DH ;

Murphy, DL .

SCIENCE, 1996, 274 (5292) :1527-1531

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