Overview of Inherited Zinc Deficiency in Infants and Children

被引:40
作者
Kambe, Taiho [1 ]
Fukue, Kazuhisa [1 ]
Ishida, Riko [1 ]
Miyazaki, Shiho [1 ]
机构
[1] Kyoto Univ, Grad Sch Biostudies, Div Integrated Life Sci, Kyoto 6068502, Japan
基金
日本学术振兴会;
关键词
zinc deficiency; infants; children; acrodermatitis enteropathica; transient neonatal zinc deficiency; ACRODERMATITIS-ENTEROPATHICA; PUBLIC-HEALTH; TRANSPORTERS; MOUSE; MILK; GENE; SUPPLEMENTATION; IDENTIFICATION; DERMATITIS; MUTATION;
D O I
10.3177/jnsv.61.S44
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Zinc nutrition is of special practical importance in infants and children. Poor zinc absorption causes zinc deficiency, which leads to a broad range of consequences such as alopecia, diarrhea, skin lesions, taste disorders, loss of appetite, impaired immune function and neuropsychiatric changes and growth retardation, thus potentially threatening life in infants and children. In addition to dietary zinc deficiency, inherited zinc deficiency, which rarely occurs, is found during the infant stage and early childhood. Recent molecular genetic studies have identified responsible genes for two inherited zinc deficiency disorders, acrodermatitis enteropathica (AE) and transient neonatal zinc deficiency (TNZD), clarifying the pathological mechanisms. Both of these zinc deficiencies are caused by mutations of zinc transporters, although the mechanisms are completely different. AE is an autosomal recessive disorder caused by mutations of the ZIP4 gene, consequently resulting in defective absorption of zinc in the small intestine. In contrast, TNZD is a disorder caused by mutations of the ZnT2 gene, which results in low zinc breast milk in the mother, consequently causing zinc deficiency in the breast-fed infant. In both cases, zinc deficiency symptoms are ameliorated by a daily oral zinc supplementation for the patients. Zinc is definitely one of the key factors for the healthy growth of infants and children, and thus zinc nutrition should receive much attention.
引用
收藏
页码:S44 / S46
页数:3
相关论文
共 22 条
[11]   Novel Proteolytic Processing of the Ectodomain of the Zinc Transporter ZIP4 (SLC39A4) during Zinc Deficiency Is Inhibited by Acrodermatitis Enteropathica Mutations [J].
Kambe, Taiho ;
Andrews, Glen K. .
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (01) :129-139
[12]   Current understanding of ZIP and ZnT zinc transporters in human health and diseases [J].
Kambe, Taiho ;
Hashimoto, Ayako ;
Fujimoto, Shigeyuki .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (17) :3281-3295
[13]   Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency [J].
Kawamura, Tatsuyoshi ;
Ogawa, Youichi ;
Nakamura, Yuumi ;
Nakamizo, Satoshi ;
Ohta, Yoshihiro ;
Nakano, Hajime ;
Kabashima, Kenji ;
Katayama, Lchiro ;
Koizumi, Schuichi ;
Kodama, Tatsuhiko ;
Nakao, Atsuhito ;
Shimada, Shinji .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (02) :722-732
[14]   Zinc-deficiency dermatitis in breast-fed infants [J].
Kienast, Antonia ;
Roth, Bernhard ;
Bossier, Christiane ;
Hojabri, Christina ;
Hoeger, Peter H. .
EUROPEAN JOURNAL OF PEDIATRICS, 2007, 166 (03) :189-194
[15]   Identification of SLC39A4, a gene involved in acrodermatitis enteropathica [J].
Küry, S ;
Dréno, B ;
Bézieau, S ;
Giraudet, S ;
Kharfi, M ;
Kamoun, R ;
Moisan, JP .
NATURE GENETICS, 2002, 31 (03) :239-240
[16]   A Dominant Negative Heterozygous G87R Mutation in the Zinc Transporter, ZnT-2 (SLC30A2), Results in Transient Neonatal Zinc Deficiency [J].
Lasry, Inbal ;
Seo, Young Ah ;
Ityel, Hadas ;
Shalva, Nechama ;
Pode-Shakked, Ben ;
Glaser, Fabian ;
Berman, Bluma ;
Berezovsky, Igor ;
Goncearenco, Alexander ;
Klar, Aharon ;
Levy, Jacob ;
Anikster, Yair ;
Kelleher, Shannon L. ;
Assaraf, Yehuda G. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (35) :29348-29361
[17]   ZINC AND COPPER-BINDING PROTEINS IN HUMAN-MILK [J].
LONNERDAL, B ;
HOFFMAN, B ;
HURLEY, LS .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1982, 36 (06) :1170-1176
[18]   Acrodermatitis enteropathica and an overview of zinc metabolism [J].
Maverakis, Emanual ;
Fung, Maxwell A. ;
Lynch, Peter J. ;
Draznin, Michelle ;
Michael, Daniel J. ;
Ruben, Beth ;
Fazel, Nasim .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 56 (01) :116-124
[19]   The Relationship between Zinc Intake and Serum/Plasma Zinc Concentration in Children: A Systematic Review and Dose-Response Meta-Analysis [J].
Moran, Victoria Hall ;
Stammers, Anna-Louise ;
Medina, Marisol Warthon ;
Patel, Sujata ;
Dykes, Fiona ;
Souverein, Olga W. ;
Dullemeijer, Carla ;
Perez-Rodrigo, Carmen ;
Serra-Majem, Lluis ;
Nissensohn, Mariela ;
Lowe, Nicola M. .
NUTRIENTS, 2012, 4 (08) :841-858
[20]   Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter [J].
Wang, FD ;
Kim, BE ;
Dufner-Beattie, J ;
Petris, MJ ;
Andrews, G ;
Eide, DJ .
HUMAN MOLECULAR GENETICS, 2004, 13 (05) :563-571