Effect of additives on eremomycin sorbent selectivity in separation of salbutamol enantiomers using supercritical fluid chromatography

被引：11

作者：

Pokrovskiy, O. I. ^{[1
,2
]}

Kayda, A. S. ^{[2
]}

Usovich, O. I. ^{[2
]}

Parenago, O. O. ^{[1
,2
]}

Lunin, V. V. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Kurnakov Inst Gen & Inorgan Chem, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2017年 / 91卷 / 11期

关键词：

supercritical fluid chromatography; enantioselectivity; eremomycin; salbutamol; ionic interactions; polar ionic mode; CHIRAL STATIONARY PHASES; LIQUID-CHROMATOGRAPHY; ENANTIOSEPARATION; RISTOCETIN;

D O I：

10.1134/S0036024417140011

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A regime is found in which chiral stationary phase based on macrocyclic glycopeptide eremomycin allows separation of salbutamol sulfate enantiomers in supercritical fluid chromatography. Enantioseparation occurs only when two dynamic modifiers are used simultaneously: isopropylamin + trifluoroacetic acid or isopropylamin + ammonium acetate. Amine molar concentration in mobile phase has to be higher than acid molar concentration, otherwise enantiomers coelute. We suppose that with amine excess a mechanism of enantiorecognition is realized which involves ionic sorbent-sorbate interactions. Such mechanism is well-known for glycopeptide chiral selectors in liquid chromatography, but for supercritical fluid chromatography it is reported for the first time.

引用

页码：2288 / 2290

页数：3

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